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Methylprednisolone
go.drugbank.com/drugs/DB00959ApprovedInvestigationalVet approved[A188811] It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. … [A192813] The efficacy of methylprednisolone in novel coronavirus pneumonia is being investigated further in clinical trials.[L12666]
Categories: Corticosteroid Hormone Receptor AgonistsProducts: DE SOLUCIÓN INYECTABLE.I.M.. I.V. LENTA . NFUSIÓN I.V.Letermovir
go.drugbank.com/drugs/DB12070ApprovedInvestigationalIt is currently marketed under the brand name Prevymis.[L1021] … [L1021] It is the first of a new class of CMV anti-infectives called DNA terminase complex inhibitors.[A31290] Letermovir has recieved both priority and orphan drug status from the FDA.
Mitochondrial potassium channel ATP-binding subunit
go.drugbank.com/bio_entities/BE0003673TransporterHumansATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)) (PubMed:31435016). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochon...
Synonyms: Mitochondrial sulfonylurea-receptorTemanogrel
go.drugbank.com/drugs/DB05227InvestigationalAPD791 is intended to lower the risk of arterial thrombosis by reducing the amplification of platelet aggregation, arterial constriction and intimal hyperplasia mediated by serotonin.
Categories: Serotonin Receptor Antagonists, Serotonin 5-HT2 Receptor AntagonistsPF-03187207
go.drugbank.com/drugs/DB05746InvestigationalThe development of abnormally high IOP, due to blockage or malfunction of systems controlling the amount of fluid in the eye, is believed to be one of the principal causes of glaucoma. … Based on the very promising preclinical results and on the well-known activities of nitric oxide, PF-03187207 is expected to have an increased capacity to reduce high IOP.
Prothrombin
go.drugbank.com/drugs/DB11311ApprovedInvestigationalProthrombin Complex Concentrate (Human), is indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with
Allogenic Donor CD362-enriched Human Umbilical Cord-derived Mesenchymal Stem Cells
go.drugbank.com/drugs/DB15731InvestigationalThe isolated cells are expanded in culture and are able to be used allogenically -- meaning that one donor’s cells can be given to other unrelated patients. … ORBCEL-C™ is the trade name of a product composed of highly purified stromal cells derived from the human umbilical cord.
Mequitazine
go.drugbank.com/drugs/DB01071InvestigationalIt competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. … It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Tumor necrosis factor ligand superfamily member 11
go.drugbank.com/bio_entities/BE0003517TargetHumansCytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions ...
Synonyms: Receptor activator of nuclear factor kappa-B ligandHepatocyte nuclear factor 4-alpha
go.drugbank.com/bio_entities/BE0004019TargetHumansTranscriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922)...
Synonyms: Nuclear receptor subfamily 2 group A member 1