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Alpha-2 adrenergic receptors
go.drugbank.com/bio_entities/BE0004864TargetHumansAlpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated … Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated
Synonyms: Alpha-2 adrenergic receptor subtype C10, Alpha-2 adrenergic receptor subtype C2Dihydropyrimidinase-related protein 2
go.drugbank.com/bio_entities/BE0005806TargetHumansPlays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Ma...
Polypeptides: Dihydropyrimidinase-related protein 2Synonyms: DRP-2, CRMP-2Galanin receptor type 2
go.drugbank.com/bio_entities/BE0011498TargetHumansReceptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibi...
Polypeptides: Galanin receptor type 2Synonyms: GALR-2Calpain-2 catalytic subunit
go.drugbank.com/bio_entities/BE0012693TargetHumansCalcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cl...
Polypeptides: Calpain-2 catalytic subunitSynonyms: CANP 2, Calpain-2 large subunitOX-2 membrane glycoprotein
go.drugbank.com/bio_entities/BE0013092TargetHumansCostimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues
Polypeptides: OX-2 membrane glycoproteinOligodendrocyte transcription factor 2
go.drugbank.com/bio_entities/BE0014194TargetHumansAntagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development
Polypeptides: Oligodendrocyte transcription factor 2Synonyms: Protein kinase C-binding protein 2Sigma intracellular receptor 2
go.drugbank.com/bio_entities/BE0015084TargetHumansSigma-2 receptor implicated in the regulation of multiple cellular processes, including cholesterol biosynthesis and trafficking, membrane trafficking, autophagy, lipid membrane-associated protein trafficking
Polypeptides: Sigma intracellular receptor 2Synonyms: Sigma-2 receptorSodium/hydrogen exchanger 2
go.drugbank.com/bio_entities/BE0020524TransporterHumansPlasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:10444453). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic...
Polypeptides: Sodium/hydrogen exchanger 2Synonyms: NHE-2, Na(+)/H(+) exchanger 2Fluvastatin
go.drugbank.com/drugs/DB01095ApprovedInvestigationalFluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. … HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 CYP2B6 InducersProducts: Fluvastatin Sandoz 20 mg - Hartkapseln, LESCOL XL 80 MG TABLET, 28 ADETCysteinyl leukotriene receptor 2
go.drugbank.com/bio_entities/BE0000099TargetHumansReceptor for cysteinyl leukotrienes. The response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary ...
Polypeptides: Cysteinyl leukotriene receptor 2