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Displaying results 4821 - 4830 of 10000 in total
  1. Drug

    Ketamine

    go.drugbank.com/drugs/DB01221
    ApprovedInvestigationalVet approved

    Ketamine is an NMDA receptor antagonist with a potent anesthetic effect.[A31869] It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. … It was FDA approved in 1970, and from there, it has been used as an anesthetic for children or patients undergoing minor surgeries but mainly for veterinary purposes.[L1332]

    Categories: N-Methylaspartate, agonists, N-Methylaspartate, antagonists & inhibitorsSynonyms: 2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone, 2-(methylamino)-2-(2-chlorophenyl)cyclohexanone
  2. Target

    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

    go.drugbank.com/bio_entities/BE0000295
    TargetHumans

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The ...

    Polypeptides: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
  3. Target

    2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

    go.drugbank.com/bio_entities/BE0001661
    TargetEscherichia coli (strain K12)

    Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

    Polypeptides: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseSynonyms: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase
  4. Target

    2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

    go.drugbank.com/bio_entities/BE0001839
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

    Polypeptides: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseSynonyms: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase
  5. Target

    G protein-activated inward rectifier potassium channel 4

    go.drugbank.com/bio_entities/BE0002218
    TargetHumans

    Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.

    Polypeptides: G protein-activated inward rectifier potassium channel 4Synonyms: GIRK-4, IRK-4
  6. Target

    Potassium voltage-gated channel subfamily KQT member 4

    go.drugbank.com/bio_entities/BE0002399
    TargetHumans

    KCNQ4/Kv7.4 channel is composed of 4 pore-forming subunits assembled as tetramers (PubMed:34767770). … The channel conducts a slowly activating and deactivating current (PubMed:10025409, PubMed:11245603). Current often shows some inward rectification at positive potentials (PubMed:10025409).

    Polypeptides: Potassium voltage-gated channel subfamily KQT member 4Synonyms: KQT-like 4
  7. Target

    UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase

    go.drugbank.com/bio_entities/BE0002630
    TargetPseudomonas aeruginosa

    Polypeptides: UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimeraseSynonyms: UDP-GlcNAcA 4-epimerase
  8. Target

    C-type lectin domain family 4 member E

    go.drugbank.com/bio_entities/BE0009096
    TargetHumans

    Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells (By similarity). … The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions (PubMed:23602766, PubMed:24101491).

    Polypeptides: C-type lectin domain family 4 member E
  9. Target

    C-type lectin domain family 4 member C

    go.drugbank.com/bio_entities/BE0010522
    TargetHumans

    Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). … May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283)

    Polypeptides: C-type lectin domain family 4 member C
  10. Drug

    Nitroprusside

    go.drugbank.com/drugs/DB00325
    ApprovedInvestigational

    Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). … Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency.

    Categories: Compounds used in a research, industrial, or household setting, Arteriolar Smooth Muscle, Agents Acting OnProducts: N-PRUS, NITROPRUSIATO DE SODIO 50 MG/2 ML INYECTABLE