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Tocilizumab
go.drugbank.com/drugs/DB06273ApprovedInvestigationalTocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. … [L12789] It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersProducts: ACTEMRA 400 MG/20 ML IV INFUZYONLUK COZELTI KONSANTRESI İÇEREN FLAKON, 1 ADET, ACTEMRA 400 MG/20 ML IV INFUZYONLUK COZELTI KONSANTRESI İÇEREN FLAKON, 4 ADETAntithymocyte immunoglobulin (rabbit)
go.drugbank.com/drugs/DB00098ApprovedInvestigationalThymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of T-cells. … Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients.
Categories: Immunoglobulin G, Increased T Lymphocyte DestructionSynonyms: r-ATG, Lapine T-lymphocyte immune globulinAnakinra
go.drugbank.com/drugs/DB00026ApprovedInvestigationalAnakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. … This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.
Categories: Interleukin-1 Receptor AntagonistSynonyms: Interleukin-1 receptor antagonist anakinraClobazam
go.drugbank.com/drugs/DB00349ApprovedIllicitInvestigational[A256963,A256868] This is likely because of clobazam's higher affinity to the α<sub>2</sub> subunit of the GABA<sub>A</sub> receptor, which mediates anxiolytic effects, than the α<sub>1</sub> subunit, … [A256868] Additionally, clobazam is believed to be a partial agonist to the GABA<sub>A</sub> receptor rather than non-selective full receptor agonists like 1,4-benzodiazepines, thus potentially explaining
Categories: Heterocyclic Compounds, 2-Ring, GABA-A Receptor AgonistsSynonyms: 7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione, 1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepineLeuprolide
go.drugbank.com/drugs/DB00007ApprovedInvestigationalLeuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). … Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three
International brands: Prostap 3Products: LUCRIN INJECTION 5 mg/ml, ELIGARD®7.5 MGNiacin
go.drugbank.com/drugs/DB00627ApprovedInvestigationalNutraceuticalNiacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.
Mixtures: Niacin 500 Mg and Inositol, Multi #2Categories: Vitamin B Complex, Cytochrome P-450 CYP2D6 InhibitorsCetirizine
go.drugbank.com/drugs/DB00341ApprovedInvestigationalOne of the most common uses for this drug is for a condition called _allergic rhinitis_.
Mixtures: ACERADOX® G, ZYRTEC D 12 HourCategories: P-glycoprotein inhibitors, P-glycoprotein substratesCarnitine O-palmitoyltransferase 2, mitochondrial
go.drugbank.com/bio_entities/BE0000179TargetHumansInvolved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites (PubMed:20538056, PubMed:24780397). Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidat...
Polypeptides: Carnitine O-palmitoyltransferase 2, mitochondrialProstaglandin G/H synthase 2
go.drugbank.com/bio_entities/BE0000262TargetEnzymeHumansMetabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response (PubMed:22942274). … In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophospholipids to prostanoid lysophospholipids, which are then hydrolyzed by intracellular phospholipases to release free
Polypeptides: Prostaglandin G/H synthase 2Synonyms: COX-2, PGHS-2Interleukin-2 receptor subunit alpha
go.drugbank.com/bio_entities/BE0000658TargetHumansReceptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.
Polypeptides: Interleukin-2 receptor subunit alphaSynonyms: IL-2-RA, IL-2 receptor subunit alpha