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Displaying results 4931 - 4940 of 10000 in total
  1. Drug

    Burosumab

    go.drugbank.com/drugs/DB14012
    ApprovedInvestigational

    This is the first drug approved to treat adults and children ages 1 year and older with X-linked hypophosphatemia (XLH), which is a rare, inherited form of rickets. … It causes impaired bone growth and development in children and adolescents and issues with bone mineralization throughout a patient’s life [L2346].

    Products: CRYSVITA® SOLUTION FOR INJECTION 10 MG/ML, CRYSVITA® SOLUCIÓN PARA INYECCIÓN 20 MG/ML
  2. Drug

    Treosulfan

    go.drugbank.com/drugs/DB11678
    ApprovedInvestigational

    Treosulfan is a prodrug alternative to [busulfan] for myeloablative conditioning prior to hematopoietic stem cell transplantation. … [L52245] It was approved by the EMA in June 2019[L16965] and by the FDA in January 2025 for use in combination with [fludarabine].[L52575]

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsSynonyms: L-threitol-1,4-dimethanesulfonate
  3. Indication

    Human Immunodeficiency Virus Type 1 (HIV-1)

    go.drugbank.com/conditions/DBCOND0042885
    Drugs: Cabotegravir · Doravirine · Enfuvirtide · Rilpivirine
    Synonyms: Human Immunodeficiency Virus-1 (HIV-1), Human Immunodeficiency Virus Type 1 (HIV-1)
  4. Drug

    Vedolizumab

    go.drugbank.com/drugs/DB09033
    ApprovedInvestigational

    [A261576] Vedolizumab is administered by IV infusion over a period of 30 minutes; after the first dose, it is given again at two and six weeks and then every 8 weeks thereafter. … Vedolizumab is a recombinant humanized IgG1 monoclonal antibody directed against the human lymphocyte α4β7 integrin, a key mediator of gastrointestinal inflammation implicated in diseases like ulcerative

    Products: ENTYVIO 300 MG İNFÜZYONLUK. ÇÖZELTİ HAZIRLAMADA KULLANILACAK KONSANTRE İÇİN TOZ, 1 ADET, ENTYVIO® 108 MG SOLUCIÓN INYECTABLE
  5. Target

    Cyclin-dependent kinase 5 activator 1

    go.drugbank.com/bio_entities/BE0003819
    TargetHumans

    p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex...

    Polypeptides: Cyclin-dependent kinase 5 activator 1Synonyms: Cyclin-dependent kinase 5 regulatory subunit 1, CDK5 activator 1
  6. Target

    Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

    go.drugbank.com/bio_entities/BE0010803
    TargetHumans

    Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating … Also, is able to hydrolyze the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3), 1D-myo-inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:

    Polypeptides: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1Synonyms: SH2 domain-containing inositol 5'-phosphatase 1, SHIP-1
  7. Target

    1-phosphatidylinositol 3-phosphate 5-kinase

    go.drugbank.com/bio_entities/BE0021269
    TargetHumans

    Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). … Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764).

    Polypeptides: 1-phosphatidylinositol 3-phosphate 5-kinaseSynonyms: Phosphatidylinositol 3-phosphate 5-kinase, Phosphatidylinositol 3-phosphate 5-kinase type III
  8. Drug

    Varicella zoster vaccine (live/attenuated)

    go.drugbank.com/drugs/DB10318
    ApprovedInvestigational

    Efficacy of Zostavax also wanes over time, with protection against shingles and PHN lasting only around 5 years. … Since October 2017, however, it has been replaced as first line therapy by Shingrix ([DB13924]), a more effective and longer lasting vaccine[L1038].

    Mixtures: PROQUAD 0.5 ML ENJEKSIYONLUK SÜSPANSIYON HAZIRLAMAK IÇIN LIYOFILIZE TOZ IÇEREN FLAKON VE ÇÖZÜCÜ IÇEREN ENJEKTÖR , 1 ADET, PRIORIX-TETRA 0.5 ML SC ENJEKSIYON IÇIN LIYOFILIZE TOZ IÇEREN FLAKON VE ÇÖZÜCÜ IÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 DOZ İĞNELİSynonyms: Human herpesvirus 3 live (attenuated) antigen
  9. Drug

    Beta carotene

    go.drugbank.com/drugs/DB06755
    ApprovedNutraceutical

    [T162] It is the most abundant form of carotenoid and it is a precursor of the vitamin A. Beta-carotene is composed of two retinyl groups. … It is an antioxidant that can be found in yellow, orange and green leafy vegetables and fruits.[T158] Under the FDA, beta-carotene is considered as a generally recognized as safe substance (GRAS).

    Mixtures: Coen.q10w.vit.c and E Beta-car.se Cu Zn Mn, Folika-MGCategories: Vitamin A
  10. Drug

    Bleomycin

    go.drugbank.com/drugs/DB00290
    ApprovedInvestigational

    A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). … It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.

    Products: BLEOCIN 15 MG LIYOFILIZE AMPUL, 1 ADET, BLEMISIN 15 MG LIYOFILIZE TOZ ICEREN FLAKON, 1 ADET