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Displaying results 41 - 50 of 509 in total
  1. Target

    A disintegrin and metalloproteinase with thrombospondin motifs 5

    go.drugbank.com/bio_entities/BE0003730
    TargetHumans

    Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN (PubMed:16133547, … Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration.

    Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 5Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 11
  2. Target

    Sensor cyclic diguanylate phosphodiesterase, GAF and GAF domain-containing

    go.drugbank.com/bio_entities/BE0004305
    TargetGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)

    Polypeptides: Sensor cyclic diguanylate phosphodiesterase, GAF and GAF domain-containing
  3. Target

    Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

    go.drugbank.com/bio_entities/BE0009519
    TargetHumans

    May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380)

    Polypeptides: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
  4. Target

    Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

    go.drugbank.com/bio_entities/BE0003558
    TargetHumans

    Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148) … Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:10725373, PubMed:10906126, PubMed:11050148, PubMed:16330539).

    Polypeptides: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11ASynonyms: cAMP and cGMP phosphodiesterase 11A
  5. Target

    Ankyrin repeat and protein kinase domain-containing protein 1

    go.drugbank.com/bio_entities/BE0009411
    TargetHumans

    Polypeptides: Ankyrin repeat and protein kinase domain-containing protein 1
  6. Target

    cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

    go.drugbank.com/bio_entities/BE0000631
    TargetHumans

    Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10373451, PubMed:10393245, PubMed:17389385, PubMed:27058447). … May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:27058447)

    Polypeptides: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
  7. Target

    2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2

    go.drugbank.com/bio_entities/BE0002203
    TargetHumans

    Polypeptides: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
  8. Target

    General transcription and DNA repair factor IIH helicase/translocase subunit XPB

    go.drugbank.com/bio_entities/BE0012820
    TargetHumans

    The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape (PubMed:10024882). … In transcription pre-initiation complexes induces and propagates a DNA twist to open DNA (PubMed:27193682, PubMed:33902107).

    Polypeptides: General transcription and DNA repair factor IIH helicase/translocase subunit XPB
  9. Target

    Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

    go.drugbank.com/bio_entities/BE0005530
    TargetHumans

    Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). … Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049).

    Polypeptides: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENSynonyms: Phosphatase and tensin homolog
  10. Target

    sulfate adenylyltransferase

    go.drugbank.com/bio_entities/BE0003166
    TargetThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

    Polypeptides: sulfate adenylyltransferaseSynonyms: Sulfate adenylyltransferase, Sulfate adenylate transferase