Search

Displaying results 491 - 500 of 10000 in total
  1. Drug

    alpha-Tocopherol acetate

    go.drugbank.com/drugs/DB14003
    Approved

    Alpha-tocopherol is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements. … Nevertheless, vitamin E is known to be a fat-soluble antioxidant that has the capability to neutralize endogenous free radicals.

    Synonyms: Vitamin E acetate, Vitamin E (alpha tocopherol acetate)Mixtures: Unique Propoli Toothpas te, the naked object DeBlack PackToothpaste
  2. Drug

    Clobazam

    go.drugbank.com/drugs/DB00349
    ApprovedIllicitInvestigational

    [A256868] Additionally, clobazam is believed to be a partial agonist to the GABA<sub>A</sub> receptor rather than non-selective full receptor agonists like 1,4-benzodiazepines, thus potentially explaining … [A256963,A256868] This is likely because of clobazam's higher affinity to the α<sub>2</sub> subunit of the GABA<sub>A</sub> receptor, which mediates anxiolytic effects, than the α<sub>1</sub> subunit,

    Categories: GABA-A Receptor Agonists
  3. Drug

    Octocrylene

    go.drugbank.com/drugs/DB09535
    Approved

    Because of its effectiveness, the chemical has been approved across the globe for use in cosmetics and skin care products, but the concentrations of this ingredient are usually limited to no more than … What makes this chemical such a popular additive to sun block, is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin damage from prolonged sun exposure.

    Mixtures: Havana Sun SPF 30 Sunscreen, Wonder Glow Cream
  4. Drug

    Lumacaftor

    go.drugbank.com/drugs/DB09280
    ApprovedInvestigational

    and trafficking of mature protein to the cell surface. … chaperone, aiding the conformational stability of the mutated CFTR protein.

  5. Target

    Androgen receptor

    go.drugbank.com/bio_entities/BE0000132
    TargetHumans

    activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor

    Polypeptides: Androgen receptorSynonyms: Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4
  6. Target

    Calcitonin receptor

    go.drugbank.com/bio_entities/BE0000431
    TargetHumans

    CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively (PubMed:35324283, PubMed:38603770). … IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes (PubMed:35324283, PubMed:38603770).

    Polypeptides: Calcitonin receptorFunction: amylin receptor activity
  7. Target

    Mineralocorticoid receptor

    go.drugbank.com/bio_entities/BE0000668
    TargetHumans

    Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol.

    Polypeptides: Mineralocorticoid receptorSynonyms: Nuclear receptor subfamily 3 group C member 2
  8. Target

    Oxytocin receptor

    go.drugbank.com/bio_entities/BE0000844
    TargetHumans

    G protein-coupled receptor for oxytocin (OXT), a neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection

    Polypeptides: Oxytocin receptorFunction: oxytocin receptor activity
  9. Target

    Sigma receptor

    go.drugbank.com/bio_entities/BE0004897
    TargetHumans

    Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (PubMed:30443021)

    Polypeptides: Sigma non-opioid intracellular receptor 1, Membrane-associated progesterone receptor component 1Synonyms: Sigma1-receptor, Sigma 1-type opioid receptor
  10. Target

    Estrogen receptor

    go.drugbank.com/bio_entities/BE0010245
    TargetHumans

    Nuclear hormone receptor. … Nuclear hormone receptor.

    Polypeptides: Estrogen receptor, Estrogen receptor betaSynonyms: Estradiol receptor, Nuclear receptor subfamily 3 group A member 1