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Displaying results 541 - 550 of 10000 in total
  1. Pathway

    Metabolism and Physiological Effects of N-Acetylvaline

    smpdb.ca/view/SMP0126701
    Metabolic

    The human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G). … N-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins.

    Drugs: Valine
  2. Pathway

    Metabolism and Physiological Effects of N-Acetylmethionine

    smpdb.ca/view/SMP0126707
    Metabolic

    The human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G). … N-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins.

    Drugs: Methionine · N-Acetylmethionine
  3. Pathway

    Metabolism and Physiological Effects of N-Acetylhistidine

    smpdb.ca/view/SMP0126711
    Metabolic

    The human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G). … N-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins.

    Drugs: Histidine
  4. Pathway

    Metabolism and Physiological Effects of Beta-Alanine

    smpdb.ca/view/SMP0126732
    Metabolic

    It is a component of the naturally occurring peptides carnosine and anserine and also of pantothenic acid (vitamin B-5), which itself is a component of coenzyme A. … It is formed in vivo by the degradation of dihydrouracil and carnosine.

    Drugs: Ademetionine · Zinc · beta-Alanine · 1-Methylhistidine
  5. Pathway

    Metabolism and Physiological Effects of Indolelactic Acid

    smpdb.ca/view/SMP0126749
    Metabolic

    Indolelactic acid (CAS: 1821-52-9) is a tryptophan metabolite found in human plasma, serum, and urine. … Tryptophan is metabolized by two major pathways in humans, either through kynurenine or via a series of indoles, and some of its metabolites are known to be biologically active.

    Drugs: Tryptophan · Indoleacetic acid
  6. Pathway

    Metabolism and Physiological Effects of 1-Methylhistidine

    smpdb.ca/view/SMP0126760
    Metabolic

    During protein catabolism, 1-methylhistidine is released but cannot be reutilized. … Within cells, SETD3 is found in the cytoplasm and nucleus. Other proteins that are known to have 1MH modifications include myosin and myosin kinase.

    Drugs: Histidine · Ademetionine · 1-Methylhistidine
  7. Pathway

    Metabolism and Physiological Effects of Vanillic Acid

    smpdb.ca/view/SMP0126881
    Metabolic

    Oxidates also other aromatic aldehydes including benzaldehyde, coniferyl aldehyde and cinnamaldehyde, but has a preference for vanillin. Vanillin is produced via the breakdown of phenylalanine. … Vanillic acid is a phenolic acid found in some forms of vanilla and many other plant extracts. It is a flavouring and scent agent that produces a pleasant, creamy odour.

    Drugs: NADH · Vanillic acid
  8. Drug

    Finerenone

    go.drugbank.com/drugs/DB16165
    ApprovedInvestigational

    [A236544,L34739] Finerenone was granted FDA approval on 9 July 2021,[L34739] followed by the EMA approval on 11 March 2022.[L41449] … Finerenone, or BAY 94-8862, is a mineralocorticoid receptor antagonist indicated to reduce the risk of sustained decline in glomerular filtration rate, end stage kidney disease, cardiovascular death, heart

    Products: KERENDIA FILM-COATED TABLET 20MG, KERENDIA FILM-COATED TABLET 10MG
  9. Drug

    Glimepiride

    go.drugbank.com/drugs/DB00222
    ApprovedInvestigational

    complications that lead to co-morbidities and mortalities. … Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in accordance with progressive β cell failure and long-term microvascular and macrovascular

    Mixtures: Pioglitazone and Glimepiride, Pioglitazone and GlimepirideCategories: Alimentary Tract and Metabolism, glimepiride and pioglitazone
  10. Drug

    Ramucirumab

    go.drugbank.com/drugs/DB05578
    ApprovedInvestigational

    By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stimulated receptor phosphorylation and downstream ligand-induced proliferation, … permeability, and migration of human endothelial cells.

    Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: CYRAMZA CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/10ML, Cyramza 100mg/10ml concentrate for solution for infusion