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Amiodarone
go.drugbank.com/drugs/DB01118ApprovedInvestigationalAmiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. … [A36817] Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation.
Categories: BSEP/ABCB11 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic IndexProducts: AMIODARON 200 1A PHARMA, AMIODARON AL 200Spironolactone
go.drugbank.com/drugs/DB00421ApprovedInvestigationalSpironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. … [A11837] Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered.
Mixtures: SEMİTONE 100/20 MG FILM TABLET, 10 ADET, SEMİTONE 50/20 MG FILM TABLET, 10 ADETCategories: Antihypertensive Agents Indicated for HypertensionMianserin
go.drugbank.com/drugs/DB06148ApprovedWithdrawnA tetracyclic compound with antidepressant effects. Mianserin was previously available internationally, however in most markets it has been phased out in favour of [mirtazapine].
Synonyms: 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepineProducts: MIANSERIN-NEURAX 10 MG, TOLVON TABLET 10 MG, 30 ADETAlprostadil
go.drugbank.com/drugs/DB00770ApprovedInvestigationalThis drug causes vasodilation by directly affecting vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth. … [A257068,A257088] Alprostadil is also used in neonatal patients with congenital heart defects that depend on a patent ductus for survival until corrective or palliative surgery can be performed.
Synonyms: PGE-1, (11α,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acidProducts: CAVERJECT POWDER FOR INJECTION 10 mcg/ml, CAVERJECT POWDER FOR INJECTION 20 mcg/mlEfavirenz
go.drugbank.com/drugs/DB00625ApprovedInvestigationalimmunodeficiency virus (HIV) type 1. … a high risk for HIV transmission.
Mixtures: FORSTAVIR-LE ( Efavirenz 600 mg, Lamivudine 300 mg and Tenofovir Disoproxil Fumarate 300 mg ) Film-coated Tablets, Symfi LoCategories: Heterocyclic Compounds, 1-Ring, Antivirals for Systemic UseDesvenlafaxine
go.drugbank.com/drugs/DB06700ApprovedInvestigational[L6016,A261271] MDD is a highly prevalent psychiatric disorder, with a lifetime prevalence estimate of 16% in the US alone and 12.8% in Europe. … Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine].
Categories: Antidepressive Agents Indicated for DepressionProducts: Pro-desvenlafaxine, STYMA 50 MGLactose
go.drugbank.com/drugs/DB04465ApprovedInvestigationalWithdrawnA disaccharide of glucose and galactose in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.
Mixtures: SERECOR® FORTE DPI 100, SYNTHROID® 112 MCG TABLETASCategories: Compounds used in a research, industrial, or household settingMannitol
go.drugbank.com/drugs/DB00742ApprovedInvestigationalOn October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for … Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables.
Mixtures: Sag-M, OSMOFUNDIN INJECTION 20%Categories: Compounds used in a research, industrial, or household setting, Drugs for ConstipationBenazepril
go.drugbank.com/drugs/DB00542ApprovedInvestigationalBenazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure[A838,A837]. … Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor[A836].
Mixtures: CİBADREX 10/12,5 MG FİLM TABLET, 28 ADET, BENAZEPRIL 1A COM 20/25MGCategories: Antihypertensive Agents Indicated for HypertensionZonisamide
go.drugbank.com/drugs/DB00909ApprovedInvestigational[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors … Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.
Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Compounds used in a research, industrial, or household settingProducts: ZONISAMID AL 100 MG HKP, ZONISAMID AL 50 MG HKP