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Displaying results 561 - 570 of 3730 in total
  1. Target

    GABA(A) Receptor

    go.drugbank.com/bio_entities/BE0004797
    TargetHumans

    In the lungs, pi-containing GABAARs contribute to pulmonary fluid transport via luminal secretion of chloride (By similarity) … GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response (By similarity).

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit alpha-2Synonyms: GABA(A) receptor subunit alpha-1, GABA(A) receptor subunit alpha-2
  2. Target

    Glutamate (NMDA) receptor

    go.drugbank.com/bio_entities/BE0004852
    TargetHumans

    Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits. … Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits (PubMed:38598639).

    Polypeptides: Glutamate receptor ionotropic, NMDA 1, Glutamate receptor ionotropic, NMDA 2ASynonyms: Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1
  3. Target

    Alpha adrenergic receptor

    go.drugbank.com/bio_entities/BE0004888
    TargetHumans

    Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenge...

    Polypeptides: Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptorSynonyms: Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c
  4. Target

    Ryanodine receptor 2

    go.drugbank.com/bio_entities/BE0005295
    TargetTransporterHumans

    Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead ...

    Polypeptides: Ryanodine receptor 2Synonyms: Type 2 ryanodine receptor, Cardiac muscle ryanodine receptor
  5. Target

    Apolipoprotein B receptor

    go.drugbank.com/bio_entities/BE0005852
    TargetTransporterHumans

    Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL

    Polypeptides: Apolipoprotein B receptorSynonyms: Apolipoprotein B-100 receptor, Apolipoprotein B-48 receptor
  6. Target

    Melanocortin receptor 4

    go.drugbank.com/bio_entities/BE0009682
    TargetHumans

    G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha- and beta-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:12646665, PubMed:14764818, PubMed … Modulates the firing activity of neurons in paraventricular nucleus (PVN) of the hypothalamus via alpha-MSH and AGRP regulation of inwardly rectifying potassium channel KCNJ13 closure, independently of

    Polypeptides: Melanocortin receptor 4Function: corticotropin receptor activity
  7. Target

    Prosaposin receptor GPR37

    go.drugbank.com/bio_entities/BE0011479
    TargetHumans

    Additionally, extracellular vesicles derived from efferocyte express prosaposin, which binds to macrophage GPR37 to increase expression of the efferocytosis receptor TIM4 via an ERK-AP1-dependent signaling … Acts as a receptor for several ligands including prosaposin, osteocalcin or neuroprotectin D1.

    Polypeptides: Prosaposin receptor GPR37Synonyms: Parkin-associated endothelin receptor-like receptor, G protein-coupled receptor 37
  8. Target

    Relaxin receptor 1

    go.drugbank.com/bio_entities/BE0019700
    TargetHumans

    Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP.

    Polypeptides: Relaxin receptor 1Synonyms: Leucine-rich repeat-containing G protein-coupled receptor 7, Relaxin family peptide receptor 1
  9. Target

    Urotensin-2 receptor

    go.drugbank.com/bio_entities/BE0020904
    TargetHumans

    G protein-coupled receptor for the vasoactive neuropeptides urotensin-2 and urotensin-2B (PubMed:14550283). … Upon ligand binding, activates intracellular signaling cascades via G protein coupling, primarily through Gq/11, leading to phospholipase C activation, increased intracellular calcium, and activation of

    Polypeptides: Urotensin-2 receptorSynonyms: Urotensin II receptor, G protein-coupled receptor 14
  10. Drug

    Emtricitabine

    go.drugbank.com/drugs/DB00879
    ApprovedInvestigational

    Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults or combined with tenofovir alafenamide for the prevention of HIV-1 infection in high risk adolescents and adults....

    Mixtures: REVIR, REVIR