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Voclosporin
go.drugbank.com/drugs/DB11693ApprovedInvestigational[L31253] In July 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended voclosporin be granted marketing authorization for use in combination with [mycophenolate mofetil] … [L31218] This [cyclosporine] A analog was approved by the FDA on January 22, 2021 following promising results in clinical trials.
Mephenytoin
go.drugbank.com/drugs/DB00532ApprovedWithdrawnThese are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subunit alpha.
Metandienone
go.drugbank.com/drugs/DB13586ApprovedWithdrawn[A254432] In the US, metandienone is a controlled substance under the Controlled Substances Act.[L44057] … It was introduced to the market in the 1960s but later discontinued and withdrawn from the market.
Categories: Androgens for Topical Use, Anabolic Agents for Systemic UseNaftifine
go.drugbank.com/drugs/DB00735ApprovedNaftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative for the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum
Categories: Antifungals for Topical Use, Antifungals for Dermatological UseChlormadinone acetate
go.drugbank.com/drugs/DB15903ApprovedWithdrawnHowever, the use of these drugs was associated with the development of mammary tumors in dogs. In 1972, the FDA withdrew its approval for the use of chlormadinone acetate in all products. … In the US, chlormadinone acetate was formerly marketed as a component of the combination drug products Estalor-21 and C-Quens.
Categories: Hormonal Contraceptives for Systemic UseLymecycline
go.drugbank.com/drugs/DB00256ApprovedInvestigationalWithdrawnLymecycline is not marketed in the USA, however, equivalent drugs are available, such as minocycline and [tetracycline].[A19429,L13880] … It is marketed by Galderma and used in the UK as well as New Zealand in addition to other countries.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseBalsalazide
go.drugbank.com/drugs/DB01014ApprovedBalsalazide works by deliverying mesalazine to the large intestine to act directly on ulcerative colitis. Mesalazine is also known as 5-aminosalicylic acid, or 5-ASA. … It is sold under the name "Colazal" in the US and "Colazide" in the UK. The chemical name is (E)-5-[[-4-(2-carboxyethyl) aminocarbonyl] phenyl]azo] -2-hydroxybenzoic acid.
Levoketoconazole
go.drugbank.com/drugs/DB05667ApprovedStill, toxicity has limited its use, notably hepatic toxicity and a tendency to prolong the QT interval.[A244083] Levoketoconazole is one of two enantiomers present in racemic [ketoconazole]. … [A244083, A29319, L39573] Levoketoconazole was approved by the FDA on December 30, 2021, and is currently marketed under the registered trademark RECORLEV by Xeris Pharmaceuticals, Inc.[L39563]
Categories: Corticosteroids for Systemic UseTemafloxacin
go.drugbank.com/drugs/DB01405ApprovedWithdrawnIt was first approved for use in the U.S. market in 1992, but was withdrawn shortly due to the reports of serious adverse reactions, such as allergic reactions and hemolyric anemia, resulting in three
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseTazobactam
go.drugbank.com/drugs/DB01606ApprovedInvestigationalPiperacillin-tazobactam was initially approved by the FDA in 1994, and ceftolozane-tazobactam was approved by the FDA in 2014[FDA label], providing wider antibacterial coverage for gram-negative infections … Tazobactam is an antibiotic of the beta-lactamase inhibitor class that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic Use