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Irinotecan
go.drugbank.com/drugs/DB00762ApprovedInvestigationalBoth irinotecan and SN-38 mediate antitumor activity by forming a complex with topoisomerase I and blocking its enzymatic activity, thereby interfering with DNA synthesis. … [L50181, L50186, L50201] Irinotecan liposome was approved by the FDA in February 2024.[L50186] The active metabolite SN-38 is also a potent inhibitor of DNA topoisomerase I.
Categories: UGT1A1 Substrates with a Narrow Therapeutic Index, UGT1A9 Substrates with a Narrow Therapeutic IndexProducts: DARITEX-A, CLORHIDRATO DE IRINOTECAN TRIHIDRATO 20 MG/MLBifenthrin
go.drugbank.com/drugs/DB15056ExperimentalBifenthrin is under investigation in clinical trial NCT01560247 (Percutaneous Recanalization in Ischemic Stroke Management in Europe Observational Registry).
Lixadesiran
go.drugbank.com/drugs/DB17295ExperimentalSynonyms: Rna, (a-c-a-u-c-a-u-c-a-g-a-c-c-a-g-g-c-a-c-c-a-g-a-c-c), complex with rna (g-g-u-c-u-g-g-u-g-c-c-u-g-g-u-c-u-g-a-u-g-a-u-g-u) (1:1)Zonisamide
go.drugbank.com/drugs/DB00909ApprovedInvestigationalThe US and Europe approved it in 2000 and 2005, respectively.[A1379,A1383] … Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.
Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Compounds used in a research, industrial, or household settingSynonyms: Benzo[d]isoxazol-3-yl-methanesulfonamideKetotifen
go.drugbank.com/drugs/DB00920ApprovedInvestigational[L32283] In addition, oral ketotifen is used in Mexico and across Europe for the treatment of various allergic symptoms and disorders,[A231204] including urticaria, mastocytosis, and food allergy. … It has a similar structure to some other first-generation antihistamines such as [cyproheptadine] and [azatadine].
Rivaroxaban
go.drugbank.com/drugs/DB06228ApprovedInvestigationalFDA approved on July 1, 2011. … Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary.
Categories: Factor Xa Inhibitors, Direct factor Xa inhibitorsProducts: RIVAROXABAN DR. REDDY'S, Rivaroxaban 1A Pharma 10 mg – FilmtablettenCimetidine
go.drugbank.com/drugs/DB00501ApprovedInvestigationalA histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions.
Products: DG Health Heartburn Relief, AA-Cimetidine 200mg TabletAtropine
go.drugbank.com/drugs/DB00572ApprovedInvestigationalVet approvedIt is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active. … [A251660] Atropine is a relatively inexpensive drug and is included in the World Health Organization List of Essential Medicines.[A251675]
Mixtures: PHARMANIAGA DIPHENOXYLATE A TABLETSynonyms: dl-Hyoscyamine, dl-tropyltropatePixantrone
go.drugbank.com/drugs/DB06193ApprovedWithdrawnIt will compare pixantrone efficacy to that of gemcitabine. [2] … It is currently being tested in Phase III trials. [2] Although pixantrone has not yet received FDA approval in the United States, it has been granted conditional marketing approval by the European Union
Quetiapine
go.drugbank.com/drugs/DB01224ApprovedInvestigationalInitially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. … [L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment.
Categories: Dopamine D2 Receptor AntagonistsProducts: QUETIAPINA DR. REDDY'S, KETIAN 25MG CAPSULA BLANDA DE GELATINA