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Gemcitabine
go.drugbank.com/drugs/DB00441ApprovedInvestigationalGemcitabine is a nucleoside analog and a chemotherapeutic agent. It was originally investigated for its antiviral effects, but it is now used as an anticancer therapy for various cancers. … [A233140] Gemcitabine is marketed as Gemzar and it is available as intravenous injection.
Categories: P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: GEMCITABINA DR. REDDY'S, GEMCITABINA 10 MG/MLChlorine dioxide
go.drugbank.com/drugs/DB12453ApprovedChlorine Dioxide has been used in trials studying the treatment of Halitosis.
Categories: Compounds used in a research, industrial, or household settingProducts: SANI-HEALTH SanitizerClonazepam
go.drugbank.com/drugs/DB01068ApprovedIllicitInvestigationalNow available as a generic medication, the agent continues to see exceptionally high use as millions of prescriptions are written for the medication internationally every year. … A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 InhibitorsProducts: RIVOTRIL ® TABLETAS DE 2.0 MG., RIVOTRIL 2.5 MG/1 ML DAMLA, 10 MLZiprasidone
go.drugbank.com/drugs/DB00246ApprovedInvestigationalgenerally thought to be as efficacious as first generation antipsychotics but differ in their adverse effect profiles. … [A180748] Although ziprasidone is classified as an atypical antipsychotic, it appears to have a lower incidence of metabolic adverse effects compared to other medications in the same class.[A190525]
Categories: Dopamine D2 Receptor Antagonists, Cytochrome P-450 SubstratesProducts: Zeldox 10 mg/ml Suspension zum Einnehmen, ZIPRASIDON AL 20MG HKPPyridostigmine
go.drugbank.com/drugs/DB00545ApprovedInvestigationalMyasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in … [A231009, A231014, L32413, L32418] Pyridostigmine was granted initial FDA approval on April 6, 1955, as an oral tablet.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersProducts: MESTINON TABLET 10 mg, MİYASTU 180 MG UZATILMIŞ SALIMLI TABLET, 30 ADETTetraferric tricitrate decahydrate
go.drugbank.com/drugs/DB14520ApprovedInvestigationalTetraferric tricitrate decahydrate is an iron containing phosphate binder used to treat hyperphosphatemia and iron deficiency anemia in adults with chronic kidney disease.
Products: FERRISITA 107,7 MG/5 ML SURUP, 150 MLTrimethoprim
go.drugbank.com/drugs/DB00440ApprovedInvestigationalVet approved[L11893] Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of … Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it
Mixtures: Nu-cotrimox Sus 40/8mg/ml, Nu-cotrimox-DS Tab 800/160mgCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesCeritinib
go.drugbank.com/drugs/DB09063ApprovedInvestigationalFollowing treatment with crizotinib (a first-generation ALK inhibitor), most tumours develop drug resistance due to mutations in key "gatekeeper" residues of the enzyme. … The FDA approved ceritinib in April 2014 due to a surprisingly high response rate (56%) towards crizotinib-resistant tumours and has designated it with orphan drug status.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: ZYKADIA 150 MG, ZYKADIA 150 MG KAPSÜL, 150 ADETDapagliflozin
go.drugbank.com/drugs/DB06292ApprovedInvestigational[A6757] Dapagliflozin has been investigated either as monotherapy or as an adjunct treatment with insulin or other oral hypoglycemic agents. … Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2.
Mixtures: XIGDUO XR (TABLETS 10 MG/1000 MG), Qtern 5 mg/10 mg Film-Coated TabletsCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesEvolocumab
go.drugbank.com/drugs/DB09303ApprovedInvestigationalIt is approved for both homozygous and heterozygous familial cholesterolemia as an adjunct to other first-line therapies. … Evolocumab is a monoclonal antibody designed for the treatment of hyperlipidemia by Amgen.
Products: REPATHA® 140 MG/ML, REPATHA 140 MG/ML SC ENJEKSIYONLUK COZELTI ICEREN KULLANIMA HAZIR ENJEKTOR, 1 ADET