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High affinity 3',5'-cyclic-AMP phosphodiesterase 7A
go.drugbank.com/bio_entities/BE0000706TargetHumansHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:19350606, PubMed:8389765, PubMed:9195912). May have a role in muscle signal transduction (PubMed:9195912)
Polypeptides: High affinity 3',5'-cyclic-AMP phosphodiesterase 7AFunction: 3',5'-cyclic-AMP phosphodiesterase activityMitogen-activated protein kinase kinase kinase kinase 5
go.drugbank.com/bio_entities/BE0009474TargetHumansMay play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway
Polypeptides: Mitogen-activated protein kinase kinase kinase kinase 5Synonyms: MEKKK 5, MEK kinase kinase 5Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
go.drugbank.com/bio_entities/BE0014411TargetHumansAlso has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). … Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity
Polypeptides: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRNSynonyms: RecQ protein-like 2Atorvastatin
go.drugbank.com/drugs/DB01076ApprovedInvestigationalthe number of major cardiovascular events (heart attack, stroke, coronary revascularization, and coronary death) for every 1 mmol/L reduction in LDL without any significant side effects or risks. … More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid.
Mixtures: Triveram 20 mg/5 mg/5 mg Filmtabletten, TRIVERAM FILM-COATED TABLET 20 mg/5 mg/5 mgCategories: P-glycoprotein inhibitors, P-glycoprotein substratesPentoxyverine
go.drugbank.com/drugs/DB11186ApprovedWithdrawnPentoxyverine acts on sigma-1 receptors, as well as kappa and mu-opioid receptors. The FDA withdrew the use of all oral gel drug products containing pentoxyverine citrate. … Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant [A32717], and local anesthetic properties.
Mixtures: Exall D, Zotex-DProducts: PENTOXYVERIN AL 1.35 MG/ML, Mucomat Hustenstiller 2,13 mg/ml Lösung zum EinnehmenAlizapride
go.drugbank.com/drugs/DB01425InvestigationalAlizapride is a dopamine antagonist that is capable of demonstrating both prokinetic and antiemetic effects.
Categories: Dopamine D2 Receptor Antagonists, Heterocyclic Compounds, 1-RingProducts: ALIZAPRIDA 50 MG/ 2 ML, ALIZAPRIDA SOLUCION INYECTABLE 50 MG/ 2 MLRifampin
go.drugbank.com/drugs/DB01045ApprovedInvestigationalRifampin, also known as rifampicin, is a broad-spectrum antimicrobial [A263748] that was first discovered in 1965 [A263753] and clinically used in 1968.
Mixtures: RIFAMPICIN 75 MG / ISONIAZID 50 MG (FDC 2 ANAK), PRO TB 2Categories: P-glycoprotein inducers, Cytochrome P-450 CYP1A2 InducersCannabinoid receptor 2
go.drugbank.com/bio_entities/BE0000095TargetHumansHeterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase.
Polypeptides: Cannabinoid receptor 2Synonyms: CB-2Matrix protein 2
go.drugbank.com/bio_entities/BE0000630TargetInfluenza A virus (strain A/Ann Arbor/6/1960 H2N2)Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome trigge...
Polypeptides: Matrix protein 2Arginase-2, mitochondrial
go.drugbank.com/bio_entities/BE0000758TargetHumansSince NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189)
Polypeptides: Arginase-2, mitochondrial