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Displaying results 581 - 590 of 1186 in total
  1. Target

    G protein-coupled receptor 6

    go.drugbank.com/bio_entities/BE0021832
    TargetHumans

    Constitutively active G protein-coupled receptor that maintains high cAMP levels and contributes to several processes including neuronal development, through activation of intracellular signaling pathways

    Polypeptides: G protein-coupled receptor 6Synonyms: Sphingosine 1-phosphate receptor GPR6
  2. Drug

    Diethyltoluamide

    go.drugbank.com/drugs/DB11282
    Approved

    Diethyltoluamide (DEET) is the common active ingredient in many insect repellent products. It is widely used to repel biting pests such as mosquitoes and ticks. Every year, DEET formulations are used to protect populations from mosquito-...

  3. Drug

    Bimatoprost

    go.drugbank.com/drugs/DB00905
    ApprovedInvestigational

    Bimatoprost, also known as Latisse or Lumigan, belongs to a group of drugs called prostamides, which are synthetic structural analogs of prostaglandin. Bimatoprost, marketed by Allergan, is administered in both the ophthalmic solution an...

  4. Target

    Prostaglandin E2 receptor EP1 subtype

    go.drugbank.com/bio_entities/BE0000064
    TargetHumans

    Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system.

    Polypeptides: Prostaglandin E2 receptor EP1 subtypeSynonyms: PGE receptor EP1 subtype, Prostanoid EP1 receptor
  5. Target

    Retinoic acid receptor RXR-beta

    go.drugbank.com/bio_entities/BE0000078
    TargetHumans

    Receptor for retinoic acid.

    Polypeptides: Retinoic acid receptor RXR-betaSynonyms: Retinoid X receptor beta, Nuclear receptor subfamily 2 group B member 2
  6. Target

    Glutamate receptor ionotropic, kainate 1

    go.drugbank.com/bio_entities/BE0000346
    TargetHumans

    The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist … Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid.

    Polypeptides: Glutamate receptor ionotropic, kainate 1Synonyms: Glutamate receptor 5, Excitatory amino acid receptor 3
  7. Target

    Prostaglandin E2 receptor EP2 subtype

    go.drugbank.com/bio_entities/BE0000368
    TargetHumans

    Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. … The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle

    Polypeptides: Prostaglandin E2 receptor EP2 subtypeSynonyms: PGE receptor EP2 subtype, Prostanoid EP2 receptor
  8. Target

    Retinoic acid receptor RXR-alpha

    go.drugbank.com/bio_entities/BE0000412
    TargetHumans

    Receptor for retinoic acid that acts as a transcription factor (PubMed:10874028, PubMed:11162439, PubMed:11915042, PubMed:37478846).

    Polypeptides: Retinoic acid receptor RXR-alphaSynonyms: Retinoid X receptor alpha, Nuclear receptor subfamily 2 group B member 1
  9. Target

    Interleukin-11 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0000416
    TargetHumans

    Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission.

    Polypeptides: Interleukin-11 receptor subunit alphaSynonyms: IL-11 receptor subunit alpha
  10. Target

    Glutamate receptor ionotropic, NMDA 2B

    go.drugbank.com/bio_entities/BE0000417
    TargetHumans

    Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity)

    Polypeptides: Glutamate receptor ionotropic, NMDA 2BSynonyms: N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3