Search
Paritaprevir Action Pathway
smpdb.ca/view/SMP0125954Drug actionParitaprevir is a direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections. Hepatitis C virus lipoviroparticles enter target hepatocytes via receptor-mediated e...
Telaprevir Action Pathway
smpdb.ca/view/SMP0125955Drug actionTelaprevir is an NS3/4A viral protease inhibitor used in combination with other antivirals for the curative treatment of chronic Hepatitis C Virus infections. Hepatitis C virus lipoviroparticles enter target hepatocytes via receptor-medi...
Cilgavimab Action Pathway
smpdb.ca/view/SMP0126002Drug actionCilgavimab is an extended half-life recombinant monoclonal IgG1κ antibody directed against the SARS-CoV-2 spike glycoprotein for COVID-19 prophylaxis in individuals who are unable to undergo COVID-19 immunization. It is produces in Chine...
Tixagevimab Action Pathway
smpdb.ca/view/SMP0126023Drug actionTixagevimab is an extended half-life recombinant monoclonal IgG1κ antibody directed against the SARS-CoV-2 S protein for COVID-19 prophylaxis in individuals unable to undergo COVID-19 immunization.Tixagevimab, in combination with cilgavi...
Bethanechol Action Pathway
smpdb.ca/view/SMP0126361Drug actionBethanechol is a muscarinic agonist used to treat postoperative and postpartum nonobstructive functional urinary retention and neurogenic atony of the bladder with retention. It can be found under the brand name Duvoid. Bethanechol is a ...
Trospium Action Pathway
smpdb.ca/view/SMP0126377Drug actionIpratropium is an anticholinergic drug used in the control of symptoms related to bronchospasm in chronic obstructive pulmonary disease (COPD). It can be found under the brand names Atrovent, Combivent, and Ipravent. It is commonly admin...
Darifenacin Action Pathway
smpdb.ca/view/SMP0126379Drug actionDarifenacin is an M3 muscarinic receptor blocker used to treat urinary incontinence. It can be found under the brand names Emselex and Enablex. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contra...
nAchR Smooth Muscle Contraction
smpdb.ca/view/SMP0126643PhysiologicalAcetylcholine released from neuromuscular neurons activates nicotinic acetylcholine receptors (nAchR) on smooth muscle membranes. This causes the receptor to open, causing sodium to flow into the smooth muscle myocyte. This high concentr...
Doxylamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126730Drug actionDoxylamine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamines interfe...
Gq Serotonergic Smooth Muscle Contraction
smpdb.ca/view/SMP0126954PhysiologicalAlthough numerous GPCRs have the ability to couple to more than one heterotrimeric G protein, a given GPCR is typically classified based on the G protein subfamily (e.g., Gs, Gi/o, or Gq/11) it preferentially activates. Signaling via Gq-...