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Displaying results 51 - 60 of 597 in total
  1. Pathway

    Polythiazide Action Pathway

    smpdb.ca/view/SMP0000080
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Polythiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  2. Pathway

    Ethacrynic Acid Action Pathway

    smpdb.ca/view/SMP0000097
    Drug action

    Etacrynic acid (also known as ethacrynic acid and Edecrin) is a loop diuretic that can inhibit water reabsorption by binding and inhibiting solute carrier family 12 member 1 (also known as sodium-potassium-chloride … Binding of the transporter can prevent import of sodium from lumen from loop of Henle to basolateral interstitium, which lead to more hypertonic environment in lumen than interstitium, and result in prevention

    Drugs: Cysteine · Etacrynic acid · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  3. Pathway

    Indapamide Action Pathway

    smpdb.ca/view/SMP0000110
    Drug action

    Sodium-chloride symporter (also known as solute carrier family 12 member 3) can translocate chloride and sodium from lumen to epithelial cell. … Sodium-potassium ATPase can export sodium from cell to basolateral interstitium, which lead to increased osmolarity in interstitum for later water reabsorption.

    Drugs: Cysteine · Indapamide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  4. Pathway

    Kidney Function

    smpdb.ca/view/SMP0000483
    Physiological

    Blood pressure is regulated by the hormones angiotensin II and aldosterone, which increases sodium chloride reabsorption. … Only water is reabsorbed in the thin descending loop of Henle, while sodium, chlorine and potassium are reabsorbed in the thick ascending loop of Henle.

    Drugs: Cysteine · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  5. Pathway

    Triamterene Action Pathway

    smpdb.ca/view/SMP0000132
    Drug action

    This primarily contributes to an increase in sodium excretion and consequentially, fluid excretion which decreases blood volume and blood pressure. … Potassium secretion is indirectly affected by the inhibition of sodium reabsorption due to the elimination of the electrochemical gradient that drives potassium loss.

    Drugs: Cysteine · Triamterene · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  6. Pathway

    Spironolactone Action Pathway

    smpdb.ca/view/SMP0000134
    Drug action

    Aldosterone increases sodium reabsorption and potassium excretion by up-regulating the expression of basolateral sodium-potassium ATPases as well as luminal (apical) sodium and potassium channels. … Spironolactone inhibits sodium and water reabsorption as well as potassium excretion by blocking the actions of aldosterone as described above.

    Drugs: Cysteine · Spironolactone · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  7. Pathway

    Quinethazone Action Pathway (old)

    smpdb.ca/view/SMP0000091
    Drug action

    In the case of quinethazone, it inhibits the sodium-chloride symporter, solute carrier family 12 member 3. Thiazides also inhibit sodium ion transport. … The short term mechanism of action is relatively well-understood: thiazides inhibit sodium-chloride co-transport into the renal distal convoluted tubule of the nephron and therefore increase fluid loss

    Drugs: Cysteine · Quinethazone · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  8. Pathway

    Amiloride Action Pathway

    smpdb.ca/view/SMP0000133
    Drug action

    Amiloride causes an increase in sodium excretion and a decrease in potassium secretion. The drug is typically prescribed to patients with depleted potassium. … Therefore, amiloride's inhibition of sodium reabsorption fails to produce an electrochemical gradient and therefore, inhibits potassium excretion.

    Drugs: Cysteine · Amiloride · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  9. Pathway

    Eplerenone Action Pathway (Old)

    smpdb.ca/view/SMP0000135
    Drug action

    Aldosterone increases sodium reabsorption and potassium excretion by up-regulating the expression of basolateral sodium-potassium ATPases as well as luminal (apical) sodium and potassium channels. … Eplerenone inhibits sodium and water reabsorption as well as potassium excretion by blocking the actions of aldosterone as described above.

    Drugs: Cysteine · Eplerenone · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  10. Pathway

    Torsemide Action Pathway

    smpdb.ca/view/SMP0000118
    Drug action

    This prevents the reuptake of sodium into the Loop of Henle which consequentially reduces the uptake of water and serves to both increase water loss and reduce blood pressure. … It is commonly used to manage hypertension and edema in cases of congestive heart failure as it acts as a diuretic by blocking sodium transporters NKCC2 on the thick ascending limb of the Loop of Henle

    Drugs: Cysteine · Torasemide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka