Search

Displaying results 591 - 600 of 10000 in total
  1. Target

    25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

    go.drugbank.com/bio_entities/BE0000443
    EnzymeTargetHumans

    Converts 24R,25-dihydroxyvitamin D3/secalciferol to 1-alpha,24,25-trihydroxyvitamin D3, an active ligand of VDR. Also active on 25-hydroxyvitamin D2 (PubMed:10518789). … D3, 1alpha,25-dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR) (PubMed:10518789, PubMed:10566658, PubMed:12050193, PubMed:22862690, PubMed:9486994).

    Polypeptides: 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialSynonyms: 25-OHD-1 alpha-hydroxylase, 25-hydroxyvitamin D(3) 1-alpha-hydroxylase
  2. Drug

    Turoctocog alfa

    go.drugbank.com/drugs/DB09109
    Approved

    Turoctocog alfa is a recombinant factor VIII (rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the N-terminus and 11 amino acids from the C-terminus of the naturally … During secretion, some rFVIII molecules are cleaved at the C-terminal of the heavy chain (HC) at amino acid 720, and a monoclonal antibody binding C-terminal to this position is used in the purification

    Products: NOVOEIGHT® 250 UI POLVO Y SOLVENTE PARA SOLUCIÓN INYECTABLE, โนโวเอท 250 หน่วยสากล
  3. Drug

    Teicoplanin

    go.drugbank.com/drugs/DB06149
    ApprovedInvestigationalWithdrawn

    Teicoplanin is a glycopeptide antibiotic consisting of a mixture of several compounds, five major (named teicoplanin A2-1 through A2-5) and four minor (named teicoplanin RS-1 through RS-4). … All teicoplanins share a same glycopeptide core, teicoplanin A3-1, but differ in the length and conformation of side chains attached to their β-D-glucosamine moiety.

    Products: Teicoplanin AptaPharma 200 mg Pulver und Lösungsmittel zur Herstellung einer Injektions-/Infusionslösung, Teicoplanin AptaPharma 400 mg Pulver und Lösungsmittel zur Herstellung einer Injektions-/Infusionslösung
  4. Drug

    alpha-Tocopherol acetate

    go.drugbank.com/drugs/DB14003
    Approved

    The recommended dietary allowances (RDAs) for vitamin E alpha-tocopherol are: males = 4 mg (6 IU) females = 4 mg (6 IU) in ages 0-6 months, males = 5 mg (7.5 IU) females = 5 mg (7.5 IU) in ages 7-12 months … = 15 mg (22.4 IU) females = 15 mg (22.4 IU) pregnancy = 15 mg (22.4 IU) lactation = 19 mg (28.4 IU) in ages 14+ years [L2120].

    Synonyms: Vitamin E acetate, α-tocopherol acetateMixtures: Vitamin E 400 Iu and Selenium 25 Mcg Capsules, Magnum-75 Vitamin and Mineral Supplement
  5. Drug

    Menadione

    go.drugbank.com/drugs/DB00170
    ApprovedNutraceutical

    A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.

    Mixtures: LIBAVIT-K 20 MG AMPUL, 5 ADETCategories: Vitamin K, Cytochrome P-450 CYP1A2 Inducers
  6. Drug

    Succinylcholine

    go.drugbank.com/drugs/DB00202
    ApprovedInvestigational

    [A19054] It has been widely used for over 50 years,[A299] most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. … Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups.

    Synonyms: 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxy)]bis(N,N,N-trimethylethanaminium)Products: LYSTHENON FORTE %2 ENJEKSİYONLUK ÇÖZELTİ, 25 AMPUL, Lysthenon 0,1 g/5 ml - Injektionslösung
  7. Drug

    Rotigotine

    go.drugbank.com/drugs/DB05271
    ApprovedInvestigational

    Rotigotine (Neupro) is a non-ergoline dopamine agonist indicated for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS) in Europe and the United States. … However, all Neupro patches in the United States and some of Europe were recalled in 2008 due to delivery mechanism issues. Rotigotine has been authorized as a treatment for RLS since August 2008.

    Mixtures: NEUPRO TRANSDERMAL 28 FLASTER BASLANGIC TEDAVI PAKETI, NEUPRO TRANSDERMAL 28 FLASTER BASLANGIC TEDAVI PAKETICategories: Serotonin 5-HT1 Receptor Agonists, Cytochrome P-450 Substrates
  8. Drug

    Bromocriptine

    go.drugbank.com/drugs/DB01200
    ApprovedInvestigationalWithdrawn

    Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. … In 1995, the FDA withdrew the approval of bromocriptine mesylate for the prevention of physiological lactation after finding that bromocriptine was not shown to be safe for use.

    Categories: Serotonin 5-HT2 Receptor Agonists, Adrenergic alpha-2 Receptor AgonistsSynonyms: 2-bromo-α-ergokryptin, 2-bromo-α-ergocryptine
  9. Drug

    Phenytoin

    go.drugbank.com/drugs/DB00252
    ApprovedInvestigationalVet approved

    Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants. … [A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market.[A189219]

    Mixtures: Dilantin W Phenobarbital 15mg, Dilantin W Phenobarbital 30mg CapCategories: Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic Index
  10. Drug

    Nabumetone

    go.drugbank.com/drugs/DB00461
    Approved

    [A179077] While slightly reduced, possibly due to a degree of cyclooxygenase-2 selectivity (COX-2), nabumetone still produces significant adverse effects in the GI tract. … [label,A178903] The molecule itself is a pro-drug with its 6-methoxy-2-naphthylacetic acid (6-MNA) metabolite acting as a potent COX inhibitor similar in structure to [naproxen].

    Synonyms: 4-(6-Methoxy-2-naphthalenyl)-2-butanone, 4-(6-Methoxy-2-naphthyl)-2-butanoneMixtures: NuDroxiPAK N-500