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Nuclear receptor ROR-alpha
go.drugbank.com/bio_entities/BE0004545TargetHumansNuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence.
Polypeptides: Nuclear receptor ROR-alphaSynonyms: Nuclear receptor RZR-alpha, RAR-related orphan receptor A5-hydroxytryptamine receptor 5A
go.drugbank.com/bio_entities/BE0004688TargetHumansAlso functions as a receptor for ergot alkaloid derivatives and other psychoactive substances (PubMed:35835867). … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35610220, PubMed:35835867
Polypeptides: 5-hydroxytryptamine receptor 5ASynonyms: Serotonin receptor 5AParathyroid hormone 2 receptor
go.drugbank.com/bio_entities/BE0004703TargetHumansThis is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. … PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity)
Polypeptides: Parathyroid hormone 2 receptorSynonyms: PTH2 receptor5-hydroxytryptamine 2 receptor
go.drugbank.com/bio_entities/BE0004881TargetHumansRegulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelanocortin neurons and the release … Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:29398112).
Polypeptides: 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2BSynonyms: Serotonin receptor 2A, Serotonin receptor 2B5-hydroxytryptamine receptor 2C
go.drugbank.com/bio_entities/BE0004882TargetRatRegulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of … G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
Polypeptides: 5-hydroxytryptamine receptor 2CSynonyms: Serotonin receptor 2C, 5-hydroxytryptamine receptor 1C5-hydroxytryptamine receptor 2
go.drugbank.com/bio_entities/BE0004957TargetHumansRegulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelanocortin neurons and the release … Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:29398112).
Polypeptides: 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2BSynonyms: Serotonin receptor 2A, Serotonin receptor 2BPlatelet-activating factor receptor
go.drugbank.com/bio_entities/BE0005561TargetHumansSeems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system … Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity.
Polypeptides: Platelet-activating factor receptorFunction: G protein-coupled purinergic nucleotide receptor activitySerine repeat antigen 5
go.drugbank.com/bio_entities/BE0009196TargetPlasmodium falciparumPolypeptides: Serine repeat antigen 5Somatostatin receptor type 4
go.drugbank.com/bio_entities/BE0009273TargetHumansReceptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.
Polypeptides: Somatostatin receptor type 45-hydroxytryptamine receptor 3D
go.drugbank.com/bio_entities/BE0009585TargetHumansForms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons
Polypeptides: 5-hydroxytryptamine receptor 3DSynonyms: Serotonin receptor 3D