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Mavacamten
go.drugbank.com/drugs/DB14921ApprovedInvestigational[A248440] Mavacamten was also approved by Health Canada in October 2022 and by EMA in July 2023 for the same indication.[L44106,L47471] … It received initial US FDA approval in 2022, and it is one of the first myosin inhibitors to be used in humans.
Products: CAMZYOS® 10MG CAPSULAS DURAS, CAMZYOS® 2.5MG CAPSULAS DURAS DE LIBERACIÓN INMEDIATA.Dimethyl fumarate
go.drugbank.com/drugs/DB08908ApprovedInvestigational[L43752] Dimethyl fumarate is marketed under the brand name Tecfidera, and it was the third oral disease-modifying agent for multiple sclerosis approved by the FDA, following [fingolimod] and [teriflunomide … Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.
Categories: Antineoplastic and Immunomodulating AgentsSynonyms: (E)-But-2-enedioic acid dimethyl esterFentanyl
go.drugbank.com/drugs/DB00813ApprovedIllicitInvestigationalVet approvedFentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. … [Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and [oxycodone].
Categories: Fentanyl and fentanyl analogues, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeSynonyms: N-phenethyl-4-(N-propionylanilino)piperidine, N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamideNaloxone
go.drugbank.com/drugs/DB01183ApprovedInvestigationalVet approvedFrequently also carried by medical and emergency personnel and at events known to be associated with heavy drug use like music festivals, naloxone kits are considered a key component of harm reduction … [L33714,L33719] When taken orally, naloxone has no pharmacological effect and does not reduce the effectiveness of the opioid effect of buprenorphine.
Synonyms: 1-N-Allyl-14-hydroxynordihydromorphinoneMixtures: VALORON N RETARD 150/12MG, VALORON N RETARD 150/12MGSelegiline
go.drugbank.com/drugs/DB01037ApprovedInvestigationalVet approvedIt may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: SELEGILIN STADA 10MG, SELEGILIN HEXAL 10MG TABLAnti-inhibitor coagulant complex
go.drugbank.com/drugs/DB13151ApprovedInvestigationalIt is used to control bleeding in hemophilia A and B patients with inhibitors.
Categories: Blood and Blood Forming Organs, Amino Acids, Peptides, and ProteinsProducts: Feiba Nf, FEIBA (Factor VIII Inhibitor Bypassing Activity) 25U/ml Powder and solvent for solution for infusionCytarabine
go.drugbank.com/drugs/DB00987ApprovedInvestigationalIt also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472) … Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle.
Categories: cytarabine and daunorubicin, Antineoplastic and Immunomodulating AgentsProducts: ARASID INJECTION BP 100MG/ML, Cytarabine Inj 100mg/mlFluticasone propionate
go.drugbank.com/drugs/DB00588ApprovedInvestigationalThese drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358][FDA Label]. Fluticasone propionate was first approved in 1990[L5962].
Mixtures: FLUTIFORM 250/10UG 120 HUB, FLUTIFORM 250/10UG 3X120HUCategories: Agents to Treat Airway DiseaseCyanocobalamin
go.drugbank.com/drugs/DB00115ApprovedInvestigationalNutraceuticalThis vitamin is produced naturally by bacteria [A175276], and is necessary for DNA synthesis and cellular energy production. … This drug was initially approved by the FDA in 1942 [FDA label].
Mixtures: APIKOBAL 250MG/250MG/1MG FİLM KAPLI TABLET, 30 ADET, APIKOBAL 250MG/250MG/1MG FİLM KAPLI TABLET, 50 ADETCategories: Diet, Food, and Nutrition, Blood and Blood Forming OrgansLinezolid
go.drugbank.com/drugs/DB00601ApprovedInvestigational[A233425] A second member of this class, [tedizolid], was approved by the FDA in 2014 and is considered generally more effective and tolerable than its predecessor. … ] and, in doing so, prevents the formation of the 70S initiation complex which is essential for bacterial reproduction.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeSynonyms: N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide