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Miglustat
go.drugbank.com/drugs/DB00419ApprovedInvestigationalMiglustat is now the first and only approved therapy for patients with Niemann-Pick disease type C (NP-C). … Miglustat, commonly marketed under the trade name Zavesca, is a drug used to treat Gaucher disease.
Categories: Heterocyclic Compounds, 1-RingSynonyms: N-(n-Butyl)deoxynojirimycin, N-butyl-1-deoxynojirimycinSpironolactone
go.drugbank.com/drugs/DB00421ApprovedInvestigationalSpironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists.
Mixtures: Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Spironolactone 2%, Dapsone 6% / Niacinamide 2% / Spironolactone 5%Categories: P-glycoprotein inducers, Cytochrome P-450 CYP2C8 InhibitorsNitric Oxide
go.drugbank.com/drugs/DB00435ApprovedInvestigationalNitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. … It is also a toxic air pollutant produced by automobile engines and power plants.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP3A InhibitorsProducts: INOFLO® LINDE, NOXAP® 200 PPMBendroflumethiazide
go.drugbank.com/drugs/DB00436ApprovedInvestigationalA thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders.
Mixtures: Corzide Tab W Nadolol 80mg, Corzide Tab W Nadolol 40mgCategories: Heterocyclic Compounds, 2-RingChloramphenicol
go.drugbank.com/drugs/DB00446ApprovedInvestigationalVet approvedWithdrawnIt has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic.
Mixtures: CORTIFENOL H POMADA OFTALMICA 4 G, CLOXONA-OCategories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP2C19 InhibitorsLansoprazole
go.drugbank.com/drugs/DB00448ApprovedInvestigationalLansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. … [A177065] It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux disease (GERD)
Mixtures: HELIPAK 500 + 30 + 1000mg TEDAVİ PAKETİ, 7 TABLETCategories: P-glycoprotein inhibitors, P-glycoprotein substratesFramycetin
go.drugbank.com/drugs/DB00452ApprovedInvestigationalA component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)
Synonyms: Neomycin B, Fradiomycin BInternational brands: Leukase NLoratadine
go.drugbank.com/drugs/DB00455ApprovedInvestigationalLoratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. … [A176435] A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations.
Mixtures: VALKET-D ®, LORAMINE® R GRAGEASCategories: P-glycoprotein inhibitors, P-glycoprotein substratesAcitretin
go.drugbank.com/drugs/DB00459ApprovedInvestigationalIt is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.
Synonyms: (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid, all-trans-3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenoic acidProducts: NEOTIGASON ® CAPSULAS 10 MGNabumetone
go.drugbank.com/drugs/DB00461Approved[label,A178903] The molecule itself is a pro-drug with its 6-methoxy-2-naphthylacetic acid (6-MNA) metabolite acting as a potent COX inhibitor similar in structure to [naproxen]. … [A179077] While slightly reduced, possibly due to a degree of cyclooxygenase-2 selectivity (COX-2), nabumetone still produces significant adverse effects in the GI tract.
Mixtures: NuDroxiPAK N-500Categories: COX-2 Inhibitors, Cytochrome P-450 Substrates