Framycetin is an aminoglycoside antibiotic used in various formulations and combinations with other agents to treat hemorrhoids, eye and ear infections, and to reduce nasal carriage of staphylococcus. A component of neomycin that is produced by Streptomyces fradiae.
- Mechanism
- Curator reviewed
Framycetin binds to specific 30S-subunit proteins and 16S rRNA, four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
- Primary indication
- For the treatment of bacterial blepharitis, bacterial bonjunctivitis, corneal injuries, corneal ulcers and meibomianitis.Curator reviewed · 11 structured indications
- Formula / weight
- C23H46N6O13 · 614.6437 g/mol (avg)
- First approval
- Canada, 2000
- Also known as
- Fradiomycin B · Neomycin B
- Code names
- ANTIBIOTIQUE EF 185
- Brand names
Resolves to
PGBHMTALBVVCIT-VCIWKGPPSA-NSMILESNC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Framycetin, and which of those have an active Phase 3 trial?
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