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PBCAR20A
go.drugbank.com/drugs/DB17189InvestigationalSynonyms: Allogeneic anti-CD20 CAR T cells, Allogeneic gene edited CD20-directed CAR (Chimeric Antigen Receptor) T cellsFlutamide
go.drugbank.com/drugs/DB00499ApprovedInvestigationalAn antiandrogen with about the same potency as cyproterone in rodent and canine species.
Categories: Antiandrogens, non-steroidal, Cytochrome P-450 SubstratesSynonyms: α,α,α-trifluoro-2-methyl-4'-nitro-m-propionotoluidide, 4'-nitro-3'-trifluoromethylisobutyranilideMetformin
go.drugbank.com/drugs/DB00331ApprovedInvestigationalIt is commonly described as an "insulin sensitizer", leading to a decrease in insulin resistance and a clinically significant reduction of plasma fasting insulin levels. … [A36559] Metformin was first approved in Canada in 1972,[A36552] and received subsequent FDA approval in the US in 1995.[L12207]
Mixtures: Nb-sitagliptin-metformin, Nb-sitagliptin-metforminCategories: Drugs Used in Diabetes, MATE 1 SubstratesOndansetron
go.drugbank.com/drugs/DB00904ApprovedInvestigationalWithdrawnHaving been developed in the 1980s by GlaxoSmithKline and approved by the US FDA since January 1991, ondansetron has demonstrated a long history of use and efficacy. … It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, P-glycoprotein substratesProducts: Nu-ondansetron, NODANTON-IMethylphenidate
go.drugbank.com/drugs/DB00422ApprovedInvestigational[A177541] There is a dose-related effect of psychostimulants on receptor stimulation, where higher doses are shown to increase norepinephrine (NE) and dopamine (DA) efflux throughout the brain which can … Biphentin was designed to be an alternative to separate doses of immediate-release (IR) methylphenidate by providing a biphasic concentration-time profile when given as a single dose.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 3-RingSynonyms: methyl α-phenyl-α-(2-piperidyl)acetate, methyl α-phenyl-α-2-piperidinylacetateSynKIR-110
go.drugbank.com/drugs/DB17365InvestigationalSynKIR-110 are autologous T cells genetically engineered to express an anti-mesothelin killer immunoglobulin-like receptor-chimeric antigen receptor (KIR-CAR).
Synonyms: SynKIR-meso CAR-T cellsNizatidine
go.drugbank.com/drugs/DB00585ApprovedA histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.
Categories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingSynonyms: N-(4-(6-Methylamino-7-nitro-2-thia-5-aza-6-hepten-1-yl)-2-thiazolylmethyl)-N,N-dimethylamineFluorometholone
go.drugbank.com/drugs/DB00324ApprovedInvestigationalA glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders.
Mixtures: FLUFORTE-N-LIQUIFILM, FML-neo Oph SusCategories: Corticosteroids, Moderately Potent (Group II), Cytochrome P-450 SubstratesSimethicone
go.drugbank.com/drugs/DB09512ApprovedInvestigational[A228308] It has a favourable safety profile as it is not systemically absorbed.[A228308] Simethicone has been in use since the 1940s[A228303] but was granted FDA approval in 1952.[A228308] … Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination.
Mixtures: DYNA-U TABLET, M A L D I MCategories: Compounds used in a research, industrial, or household settingGlioblastoma Multiforme (GBM)
go.drugbank.com/conditions/DBCOND0046976Drugs: NimotuzumabSynonyms: Glioblastoma, no ICD-O subtype, Glioblastoma, no International Classification of Diseases for Oncology subtype