This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Nimotuzumab is an EGFR-targeting monoclonal antibody used in the treatment of squamous cell carcinomas of the head and neck and glioblastomas.
- Generic Name
- Nimotuzumab
- DrugBank Accession Number
- DB06192
- Background
Not Available
- Type
- Biotech
- Groups
- Investigational
- Biologic Classification
- Protein Based Therapies
Monoclonal antibody (mAb) - Protein Structure
- Protein Chemical Formula
- Not Available
- Protein Average Weight
- Not Available
- Sequences
- Not Available
- Synonyms
- Nimotuzumab
Pharmacology
- Indication
Investigated for use/treatment in head and neck cancer, brain cancer, pediatric indications, pancreatic cancer, lung cancer, and colorectal cancer.
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- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbciximab The risk or severity of adverse effects can be increased when Abciximab is combined with Nimotuzumab. Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Nimotuzumab. Aducanumab The risk or severity of adverse effects can be increased when Nimotuzumab is combined with Aducanumab. Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Nimotuzumab. Alirocumab The risk or severity of adverse effects can be increased when Nimotuzumab is combined with Alirocumab. Ambroxol The risk or severity of methemoglobinemia can be increased when Nimotuzumab is combined with Ambroxol. Amivantamab The risk or severity of adverse effects can be increased when Nimotuzumab is combined with Amivantamab. Anifrolumab The risk or severity of adverse effects can be increased when Nimotuzumab is combined with Anifrolumab. Ansuvimab The risk or severity of adverse effects can be increased when Nimotuzumab is combined with Ansuvimab. Anthrax immune globulin human The risk or severity of adverse effects can be increased when Nimotuzumab is combined with Anthrax immune globulin human. 
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- Not Available
Products
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- DiaCIM / RadioTheraCIM / TheraCIM / Theraloc
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- Not Available
- Kingdom
- Organic Compounds
- Super Class
- Organic Acids
- Class
- Carboxylic Acids and Derivatives
- Sub Class
- Amino Acids, Peptides, and Analogues
- Direct Parent
- Peptides
- Alternative Parents
- Not Available
- Substituents
- Not Available
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 6NS400BXKH
- CAS number
- 780758-10-3
References
- General References
- Not Available
- External Links
- Wikipedia
- Nimotuzumab
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Unknown Status Treatment Nasopharyngeal Carcinoma (NPC) 1 4 Unknown Status Treatment Unresectable Pancreatic Cancer 1 3 Active Not Recruiting Treatment Squamous Cell Carcinoma of the Head and Neck (SCCHN) 1 3 Completed Treatment Adult Glioblastoma 1 3 Completed Treatment Cervical Cancer 1 3 Completed Treatment Cervical Cancer Recurrent or Persistent / Monoclonal Antibody in Cervical Cancer Treatment / Palliative Treatment 1 3 Completed Treatment Nasopharyngeal Carcinoma (NPC) 1 3 Recruiting Treatment Chemoradiotherapy / Chemotherapy Effects / Esophageal Cancer / Gastroesophageal Junction Cancer / Immunotherapy / Surgery / Targeted Therapy 1 3 Recruiting Treatment Chemoradiotherapy / Chemotherapy Effects / Esophageal Cancer / Gastroesophageal Junction Cancer / Immunotherapy / Targeted Therapy 1 3 Recruiting Treatment Head and Neck Neoplasms / Nasopharyngeal Carcinoma (NPC) / Nasopharyngeal Diseases / Nasopharyngeal Neoplasms 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection, solution Intravenous 50 mg Injection Injection, solution Intravenous 50 mg/10ml - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
Drug created at March 19, 2008 16:16 / Updated at June 19, 2021 00:26