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Zanubrutinib
go.drugbank.com/drugs/DB15035ApprovedInvestigationalL10166] which measures the proportion of patients in a trial whose tumour is entirely or partially destroyed by a drug. … [A187967] BTK is an enzyme that plays a role in oncogenic signalling pathways, promoting the survival and proliferation of malignant B cells.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic IndexProducts: BRUKINSA 80 mg capsulesNystatin
go.drugbank.com/drugs/DB00646ApprovedInvestigationalVet approved[A188562] Nystatin has a greater antifungal activity than amphotericin B - parenterally administered nystatin, however, is associated with significant toxicity and is not available in a formulation appropriate … Nystatin is a polyene antifungal drug that has broad-spectrum fungicidal and fungistatic activity against a number of yeasts and fungi, most notably _Candida_ species.
Mixtures: NİFUNİS 500 MG/200.000 I.U. VAJİNAL OVÜL, 6 ADET, NİFUNİS 500 MG/200.000 I.U. VAJİNAL OVÜL, 12 ADETCategories: Compounds used in a research, industrial, or household settingSulodexide
go.drugbank.com/drugs/DB06271ApprovedInvestigationalWithdrawnSulodexide is a mixture of glycosaminoglycans (GAGs) composed of dermatan sulfate (DS) and fast moving heparin (FMH).
Products: ANJIOFLUX 600 LRU 2 ML ENJEKTABL COZELTI ICEREN 10 AMPUL, VESSEL DUE FDeucravacitinib
go.drugbank.com/drugs/DB16650ApprovedInvestigationalUnlike other Janus kinase 1/2/3 inhibitors that bind to the conserved active domain of these non-receptor tyrosine kinases, deucravacitinib binds to the regulatory domain of TYK2 with high selectivity … Deucravacitinib is a novel oral selective tyrosine kinase 2 (TYK2) inhibitor.
Categories: Tyrosine Kinase 2 Inhibitor, P-glycoprotein substratesProducts: SOTYKTU 6 mg film coated tablets, SOTYKTU® 6MG TABLETAS RECUBIERTASSolute carrier family 2, facilitated glucose transporter member 4
go.drugbank.com/bio_entities/BE0000893TransporterTargetHumansInsulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained ...
Polypeptides: Solute carrier family 2, facilitated glucose transporter member 4Synonyms: GLUT-4, Glucose transporter type 4, insulin-responsiveSinefungin
go.drugbank.com/drugs/DB01910ExperimentalSinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar.
Categories: Heterocyclic Compounds, 2-RingSynonyms: (2S,5S)-2,5-diamino-6-[(2R,3S,R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]hexanoic acid, 6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-beta-D-ribo-decofuranuronic acidBoceprevir
go.drugbank.com/drugs/DB08873ApprovedWithdrawnBoceprevir is an inhibitor of NS3/4A, a serine protease enzyme, encoded by HCV genotypes 1 and 4 [synthesis]. … Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV).
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: VICTRELIS ® CAPSULAS 200 MG (MOLECULA PROTEGIDA)Tavolixizumab
go.drugbank.com/drugs/DB15042InvestigationalTavolixizumab is under investigation in clinical trial NCT02318394 (A Phase 1 Study of MEDI0562 in Adult Subjects With Selected Advanced Solid Tumors).
Synonyms: IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENSTNFRSF4 (TUMOR NECROSIS FACTOR RECEPTOR (TNFR) SUPERFAMILY MEMBER 4, OX40, CD134)), HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODY GAMMA1 HEAVY CHAIN (1-451) (CHIMERIC, VH (MUS MUSCULUS IGHV3-8*02 -(IGHD)-HOMO SAPIENBeta carotene
go.drugbank.com/drugs/DB06755ApprovedNutraceutical[T162] It is the most abundant form of carotenoid and it is a precursor of the vitamin A. Beta-carotene is composed of two retinyl groups. … [T158] Under the FDA, beta-carotene is considered as a generally recognized as safe substance (GRAS).[L2191]
Mixtures: ACECAP 20/200/200 MG YUMUŞAK KAPSÜL, 30 ADET, Folika-MGCategories: Vitamin AElosulfase alfa
go.drugbank.com/drugs/DB09051ApprovedInvestigationalThe recommended dose is 2 mg per kg given intravenously over a minimum range of 3.5 to 4.5 hours, based on infusion volume, once every week. … Elosulfase alfa is a synthetic version of the enzyme N-acetylgalactosamine-6-sulfatase. It was approved by the FDA in 2014 for the treatment of Morquio syndrome.
Synonyms: Recombinant human N-acetylgalactosamine-6-sulfatase, Recombinant human N-acetylgalactosamine-6-sulfatase (rhGALNS)Products: VIMIZIM® 1MG/ML SOLUCIÓN CONCENTRADA PARA INFUSIÓN, Vimizim 1mg/ml Concentrate for Solution for Infusion