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Displaying results 681 - 690 of 3729 in total
  1. Target

    Melanocyte-stimulating hormone receptor

    go.drugbank.com/bio_entities/BE0002447
    TargetHumans

    G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and adrenocorticotropic hormone/ACTH, which are peptide products of the POMC precursor protein (PubMed … MC1R interacts with G protein-coupled receptor opsin 3/OPN3, which couples to G(i) proteins and inhibits the alpha-MSH-induced cAMP response, thereby reducing melanin synthesis (PubMed:31097585).

    Polypeptides: Melanocyte-stimulating hormone receptorSynonyms: Melanocortin receptor 1
  2. Target

    Anthrax toxin receptor 2

    go.drugbank.com/bio_entities/BE0003223
    TargetHumans

    Necessary for cellular interactions with laminin and the extracellular matrix

    Polypeptides: Anthrax toxin receptor 2Function: transmembrane signaling receptor activity
  3. Target

    Leukotriene B4 receptor 1

    go.drugbank.com/bio_entities/BE0003490
    TargetHumans

    Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. … Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response

    Polypeptides: Leukotriene B4 receptor 1Synonyms: G protein-coupled receptor 16, Chemoattractant receptor-like 1
  4. Target

    Somatostatin receptor type 2

    go.drugbank.com/bio_entities/BE0003528
    TargetHumans

    Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. … In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins.

    Polypeptides: Somatostatin receptor type 2
  5. Target

    Prostaglandin D2 receptor 2

    go.drugbank.com/bio_entities/BE0003561
    TargetHumans

    Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. … Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses

    Polypeptides: Prostaglandin D2 receptor 2Synonyms: G protein-coupled receptor 44, Chemoattractant receptor-homologous molecule expressed on Th2 cells
  6. Target

    Steroid hormone receptor ERR1

    go.drugbank.com/bio_entities/BE0003722
    TargetHumans

    Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MC...

    Polypeptides: Steroid hormone receptor ERR1Synonyms: Estrogen receptor-like 1, Estrogen-related receptor alpha
  7. Target

    Nuclear receptor coactivator 1

    go.drugbank.com/bio_entities/BE0003728
    TargetHumans

    Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. … Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription

    Polypeptides: Nuclear receptor coactivator 1Synonyms: Steroid receptor coactivator 1
  8. Target

    Fe(3+)-pyochelin receptor

    go.drugbank.com/bio_entities/BE0004170
    TargetPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

    High-affinity outer membrane receptor required for the transport of Fe(3+)-pyochelin.

    Polypeptides: Fe(3+)-pyochelin receptorSynonyms: Fe(III)-pyochelin receptor
  9. Target

    D(1) dopamine receptor

    go.drugbank.com/bio_entities/BE0004889
    TargetHumans

    Also acts as a receptor for D-lysergic (LSD) psychedelic drug (PubMed:39094559) … Dopamine binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase

    Polypeptides: Dopamine receptor D1, Dopamine receptor D5Synonyms: Dopamine D1 receptor, D(1A) dopamine receptor
  10. Target

    Inositol 1,4,5-trisphosphate receptor

    go.drugbank.com/bio_entities/BE0004914
    TargetHumans

    Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER) (PubMed:10620513, PubMed:27108797). Undergoes conformational changes upon li...

    Synonyms: IP3 receptor isoform 1, Type 1 InsP3 receptor