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Displaying results 6891 - 6900 of 10000 in total
  1. Drug

    Mevastatin

    go.drugbank.com/drugs/DB06693
    Experimental

    During a search for antibiotic compounds produced by fungi in 1971, Akira Endo at Sankyo Co. (Japan) discovered a class of compounds that appeared to lower plasma cholesterol levels. … Mevastatin is a pro-drug that is activated by <i>in vivo</i> hydrolysis of the lactone ring. It has served as one of the lead compounds for the development of the synthetic compounds used today.

  2. Drug

    Placental Mesenchymal Stem Cells

    go.drugbank.com/drugs/DB15730
    Investigational

    The placenta serves many purposes, with one of the many being a bank of mesenchymal stem cells (MSCs). It can be obtained relatively easily as medical waste from which MSCs can be non-invasively extracted and without the ethical issues t...

  3. Drug

    Nomacopan

    go.drugbank.com/drugs/DB14991
    Investigational

    Nomacopan is under investigation in clinical trial NCT03427060 (Coversin in PNH in Patients With Resistance to Eculizumab Due to Complement C5 Polymorphisms).

  4. Drug

    Isuzinaxib

    go.drugbank.com/drugs/DB19109
    Investigational

    Isuzinaxib is under investigation in clinical trial NCT05758896 (Study of APX-115 in Contrast Induced Acute Kidney Injury in Subjects Undergoing PCI).

  5. Drug

    VPM1002

    go.drugbank.com/drugs/DB15801
    Investigational

    This recombinant BCG, VPM1002, has been created in response and investigated for preventing pulmonary TB in newborns and TB recurrence in adults through post-exposure immunization. … Because Hly is only active at an acidic pH, similar to listeriolysin O, the deletion of urease C was also beneficial for Hly to have optimal bioactivity in the phagosome.

  6. Drug

    Edaxeterkib

    go.drugbank.com/drugs/DB21490
    Investigational

    Edaxeterkib is under investigation in clinical trial NCT03051035 (First-in-Human Study of KO-947 in Non-Hematological Malignancies). Edaxeterkib has a monoisotopic molecular weight of 469.22 Da. … The usage of the INN stem '-terkib' in the name indicates that Edaxeterkib is a extracellular signal-regulated kinase (ERK) inhibitor.

  7. Drug

    Ceralasertib

    go.drugbank.com/drugs/DB14917
    Investigational

    Ceralasertib is under investigation in clinical trial NCT03682289 (Phase II Trial of AZD6738 Alone and in Combination With Olaparib).

  8. Drug

    Etokimab

    go.drugbank.com/drugs/DB16661
    Investigational

    Etokimab is under investigation in clinical trial NCT03614923 (Etokimab in Adult Patients With Chronic Rhinosinusitis With Nasal Polyps (Crswnp)).

  9. Drug

    Zagotenemab

    go.drugbank.com/drugs/DB16674
    Investigational

    Zagotenemab is under investigation in clinical trial NCT03518073 (A Study of LY3303560 in Participants With Early Symptomatic Alzheimer's Disease).

  10. Drug

    Lirentelimab

    go.drugbank.com/drugs/DB16728
    Investigational

    Lirentelimab is under investigation in clinical trial NCT04856891 (A Study of Lirentelimab (AK002) in Patients With Active Eosinophilic Duodenitis).