Search
Sodium channel protein
go.drugbank.com/bio_entities/BE0009367TargetPediculus humanusMediates the voltage-dependent sodium ion permeability of excitable membranes. … Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their
Polypeptides: Sodium channel proteinSodium/iodide cotransporter
go.drugbank.com/bio_entities/BE0009346TargetTransporterHumansCan also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (PubMed:12488351)
Polypeptides: Sodium/iodide cotransporterSynonyms: Sodium-iodide symporterProteinase-activated receptor 4
go.drugbank.com/bio_entities/BE0008986TargetHumansReceptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis (PubMed:10079109). May play a role in platelets activation (PubMed:10079109)
Polypeptides: Proteinase-activated receptor 4Mitogen-activated Protein Kinases
go.drugbank.com/bio_entities/BE0009853TargetHumansMAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. … In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli.
Polypeptides: Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 10Synonyms: Mitogen-activated protein kinase 2, Stress-activated protein kinase 1bProteinase-activated receptor 2
go.drugbank.com/bio_entities/BE0010726TargetHumansIts function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB … and Rho (PubMed:28445455).
Polypeptides: Proteinase-activated receptor 2Sodium-dependent multivitamin transporter
go.drugbank.com/bio_entities/BE0000094TargetTransporterHumansSodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed:10329687, PubMed:15561972, PubMed:19211916, PubMed:20980265, PubMed … Required for biotin and pantothenate uptake in the intestine across the brush border membrane (PubMed:19211916).
Polypeptides: Sodium-dependent multivitamin transporterSodium/calcium exchanger 1
go.drugbank.com/bio_entities/BE0000986TargetTransporterHumansMediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes … Required for normal embryonic heart development and the onset of heart contractions (By similarity)
Polypeptides: Sodium/calcium exchanger 1Sodium-dependent dopamine transporter
go.drugbank.com/bio_entities/BE0009676TransporterTargetMouseMediates sodium- and chloride-dependent transport of dopamine (PubMed:10375632, PubMed:12606774). … Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity).
Polypeptides: Sodium-dependent dopamine transporterSodium/glucose cotransporter 4
go.drugbank.com/bio_entities/BE0014888TransporterHumansElectrogenic Na(+)-coupled sugar symporter that may play a primary role in D-mannose and possibly D-fructose and D-glucose transport at the plasma membrane. … Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2
Polypeptides: Sodium/glucose cotransporter 4Sodium/hydrogen exchanger 2
go.drugbank.com/bio_entities/BE0020524TransporterHumansPlasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:10444453). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic...
Polypeptides: Sodium/hydrogen exchanger 2Function: sodium