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The Oncogenic Action of Succinate
smpdb.ca/view/SMP0002292DiseaseHypoxia-inducible factor In many tumours, oxygen availability becomes limited (hypoxia) very quickly during cancer development. The major regulator of the response to hypoxia is the HIF transcription factor. Under normal oxygen levels, t...
Enzymes: Malate dehydrogenase, mitochondrialThe Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria
smpdb.ca/view/SMP0002358DiseaseHydroxyglutaric aciduria is a rare genetic disorder. Both isoforms are believed to have autosomal recessive inheritance. The compound 2-hydroxyglutarate is the product of gain-of-function mutations producing mutIDH1 and mutIDH2 in the cy...
Enzymes: Malate dehydrogenase, mitochondrialThe Oncogenic Action of Fumarate
smpdb.ca/view/SMP0002295DiseaseHypoxia-inducible factor In many tumours, oxygen availability becomes limited (hypoxia) very quickly during cancer development. The major regulator of the response to hypoxia is the HIF transcription factor. Under normal oxygen levels, t...
Enzymes: Malate dehydrogenase, mitochondrialThe Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria
smpdb.ca/view/SMP0002359DiseaseHydroxyglutaric aciduria is a rare genetic disorder. Both isoforms are believed to have autosomal recessive inheritance. The compound 2-hydroxyglutarate is the product of gain-of-function mutations producing mutIDH1 and mutIDH2 in the cy...
Enzymes: Malate dehydrogenase, mitochondrialGlutaminolysis and Cancer
smpdb.ca/view/SMP0002298DiseaseThe glutaminolysis pathway catabolizes glutamine to generate ATP and lactate. Glutamine not only provides a major substrate for respiration but also for the synthesis of other macromolecules, such as nucleotides, proteins and hexosamines...
Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Succinic acid +9 moreEnzymes: Malate dehydrogenase, cytoplasmicAerobic Glycolysis (Warburg Effect)
smpdb.ca/view/SMP0000654MetabolicThe Warburg Effect refers to the phenomenon that occurs in most cancer cells where instead of generating energy with a low rate of glycolysis followed by oxidizing pyruvate via the Krebs cycle in the mitochondria, the pyruvate from a hig...
Enzymes: Malate dehydrogenase, cytoplasmic