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Displaying results 691 - 700 of 3888 in total
  1. Drug

    Plerixafor

    go.drugbank.com/drugs/DB06809
    ApprovedInvestigational

    These stem cells are then collected and used in autologous stem cell transplantation to replace blood-forming cells destroyed by chemotherapy. … Plerixafor is a small-molecule inhibitor of C-X-C chemokine receptor type 4 (CXCR4) that acts as a hematopoietic stem cell mobilizer.

    Categories: Hematopoietic Stem Cell Mobilizer, Increased Hematopoietic Stem Cell Mobilization
  2. Drug

    Cloxacillin

    go.drugbank.com/drugs/DB01147
    ApprovedInvestigationalVet approved

    A semi-synthetic penicillin antibiotic which is a chlorinated derivative of [oxacillin].

    Products: DYNA CLOXACILLIN DS 125
  3. Drug

    2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol

    go.drugbank.com/drugs/DB08773
    Experimental

    Synonyms: Raloxifene core
  4. Drug

    Elapegademase

    go.drugbank.com/drugs/DB14712
    Approved

    Elapegademase is a PEGylated recombinant adenosine deaminase. It can be defined molecularly as a genetically modified bovine adenosine deaminase with a modification in cysteine 74 for serine and with about 13 methoxy polyethylene glycol ...

    Synonyms: (CYS74>SER,ALA245>THR)ADENOSINE DEAMINASE (BOS TAURUS, BOVINE)-(1-356)-PEPTIDE, PRODUCED IN ESCHERICHIA COLI, SUBSTITUTED ON N2 OF THE N-TERMINAL ALANYL RESIDUE (A1) AND ON N6 OF LYSYL RESIDUES (K) WITH, (74-SERINE (C>S),245-THREONINE (A>T))BOS TAURUS ADENOSINE DEAMINASE (BOVINE ADENOSINE AMINOHYDROLASE, EC=3.5.4.4)-(1-356)-PEPTIDE PRODUCED IN ESCHERICHIA COLI, AN AVERAGE OF 13 RESIDUES ARE SUBSTITUTED
  5. Drug

    Niraparib

    go.drugbank.com/drugs/DB11793
    ApprovedInvestigational

    [L43277] Niraparib is selective towards PARP-1 and PARP-2. … Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells.

    Categories: Poly (ADP-ribose) polymerase (PARP) inhibitors
  6. Drug

    Carbamide peroxide

    go.drugbank.com/drugs/DB11129
    ApprovedInvestigational

    Carbamide peroxide, also known as urea-hydrogen peroxide, is a water-soluble, white crystalline solid compound consisting of hydrogen peroxide and urea. As it is a source of hydrogen peroxide, it can be found in disinfecting and dental b...

    Products: Murine Earwax Removal Sys-murine Ear Dps, Earwax Rem Cvs
  7. Pathway

    2-Ketoglutarate Dehydrogenase Complex Deficiency

    smpdb.ca/view/SMP0125755
    Disease

    oxoglutarate dehydrogenase complex (OGDC). … 2-Ketoglutarate dehydrogenase complex deficiency, also known as alpha-ketoglutarate dehydrogenase deficiency or oxoglutaric aciduria, is an autosomal recessive disorder of the Krebs cycle caused by a defective

    Drugs: Pyruvic acid · Biotin · Succinic acid · NADH · ATP · Magnesium cation +4 more
    Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
  8. Drug

    Goflikicept

    go.drugbank.com/drugs/DB16396
    Investigational

    Goflikicept is under investigation in clinical trial NCT04380519 (Study of the Efficacy and Safety of a Single Administration of Olokizumab and RPH-104 With Standard Therapy in Patients With Severe Severe Acute Respiratory Syndrome Coron...

    Synonyms: Heterodimeric fusion protein that binds to IL-1 beta consisting of human extracellular domain of IL1 receptor and a mutant Fc fragment of human IGg1 and part of human IL1 receptor accessory protein
  9. Drug

    Betamethasone

    go.drugbank.com/drugs/DB00443
    ApprovedInvestigationalVet approved

    Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states inclu...

    Mixtures: Dom-gentamicin-betamethasone, GENTAMICINA E BETAMETASONE DOC GENERICICategories: Sex Hormones and Insulins
  10. Drug

    Nerofe

    go.drugbank.com/drugs/DB14786
    Investigational

    Nerofe is under investigation in clinical trial NCT03059615 (A Phase 2a, Open-Label, Two Stage Study of Nerofe or Nerofe With Doxorubicin in Subjects With AML or MDS).

    Synonyms: TRP-TRP-THR-PHE-PHE-LEU-PRO-SER-THR-LEU-TRP-GLU-ARG-LYS, (ALL D)-