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Temsirolimus
go.drugbank.com/drugs/DB06287ApprovedInvestigationalTemsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. … Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsProducts: TORISEL 25 MG/ML IV INFUZYONLUK COZELTI ICEREN FLAKON, 1 ADET, TORISEL ® 30 MGCONCENTRADO PARA SOLUCION PARA INYECCION(25 MG/ML)Umeclidinium
go.drugbank.com/drugs/DB09076ApprovedInvestigational[A7715] Maintenance of the airway is controlled by the parasympathetic nervous system, particularly by the abundance of the muscarinic subtype 3 (M3) in the airway smooth muscle. … [A7719] By blocking the M3 muscarinic receptor, umeclidinium inhibits the binding of acetylcholine and thereby opens up the airways by preventing bronchoconstriction.
Mixtures: ANORO ELLIPTA 62.5 MCG + 25 MCG KULLANIMA HAZIR INHALASYON TOZU, 3 X 30 DOZ, TRELEGY ELLIPTA INHALATION POWDER 100 MCG/62.5 MCG/25 MCGCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesPerazine
go.drugbank.com/drugs/DB12710ApprovedWithdrawnPerazine has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.
Categories: Heterocyclic Compounds, 3-RingProducts: PERAZIN-NEURAX 200 MG, PERAZIN-NEURAX 25 MGTrihexyphenidyl
go.drugbank.com/drugs/DB00376ApprovedInvestigational[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. … Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.
Categories: Heterocyclic Compounds, 1-RingInternational brands: Ea TenMethyl salicylate
go.drugbank.com/drugs/DB09543ApprovedInvestigationalVet approvedIt forms a colorless to yellow or reddish liquid and exhibits a characteristic odor and taste of wintergreen. … It can be manufactured synthetically and it used as a fragrance, in foods, beverages, and liniments.
Mixtures: KAMFOLIN 150 MG/G+100 MG/G MERHEM, 50 G, SADRÜD % 10 + % 15 JEL, 50 GCategories: Compounds used in a research, industrial, or household settingMelphalan
go.drugbank.com/drugs/DB01042ApprovedInvestigational[L40928] It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard. … Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent.
Synonyms: 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine, 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanineProducts: ALKERAN 2 MG TABLET, 25 ADET, ALKERAN FOR INJECTION 50 mg/vialIsoprenaline
go.drugbank.com/drugs/DB01064ApprovedInvestigational[A233724,A233729] The US patent from 1943 states that this compound had a wider therapeutic index and a stronger action than [adrenaline]. … Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion
Categories: Adrenergic beta-2 Receptor Agonists, Compounds used in a research, industrial, or household settingSynonyms: N-isopropyl-β-dihydroxyphenyl-β-hydroxyethylamine, 1-(3,4-dihydroxyphenyl)-2-(isopropylamino)ethanolBevacizumab
go.drugbank.com/drugs/DB00112ApprovedInvestigational[A286054] This off-label practice was formalized with the approval of Lytenava (bevacizumab-vikg in the US; bevacizumab gamma in the EU/UK), the first ophthalmic formulation of bevacizumab developed specifically … [A192834,A192888,A192837,A192891,A192894] Bevacizumab is a humanized monoclonal IgG antibody that inhibits angiogenesis by binding and neutralizing VEGF-A.
Synonyms: 贝伐珠单抗International brands: 安倍斯, 安维汀Levosimendan
go.drugbank.com/drugs/DB00922ApprovedInvestigationalWithdrawnLevosimendan increases calcium sensitivity to myocytes by binding to troponin C in a calcium dependent manner. This increases contractility without raising calcium levels. … It also relaxes vascular smooth muscle by opening adenosine triphosphate sensitive potassium channels. Levosimendan is used to manage acutely decompensated congestive heart failure.
Categories: Heterocyclic Compounds, 1-Ring, Phosphodiesterase 3 InhibitorsProducts: SIMDAX 2.5 MG/ML KONSANTRE INF.COZ.5 ML X FLAKON, 1 ADET, LEVOSIMENDAN EGCarboplatin
go.drugbank.com/drugs/DB00958ApprovedInvestigational[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]
Categories: Compounds used in a research, industrial, or household settingSynonyms: Platinum, diammine [1,1-cyclobutane-dicarboxylato(2-)-0,0']-,(SP-4-2)