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Mitoxantrone
go.drugbank.com/drugs/DB01204ApprovedInvestigationalAn anthracenedione-derived antineoplastic agent.
Categories: Anthracyclines and Related Substances, Antineoplastic and Immunomodulating AgentsProducts: MITOXANTRONE BAXTER SOLUTION FOR INJECTION 20MG/10ML (2MG/ML), Novantrone Inj 2mg/mlTrastuzumab emtansine
go.drugbank.com/drugs/DB05773ApprovedInvestigationalTrastuzumab emtansine is marketed under the brand name Kadcyla and is indicated for use in HER2-positive, metastatic breast cancer patients who have already used taxane and/or trastuzumab for metastatic … Second that there is a black box warning of serious side effects such as hepatotoxicity, embryo-fetal toxicity, and cardiac toxicity.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: KADCYLA POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/VIAL, KADCYLA 100 MG IV INFUZYONLUK COZELTI KONSANTRESI ICIN TOZHydrotalcite
go.drugbank.com/drugs/DB13322ApprovedInvestigationalWithdrawnCategories: Alimentary Tract and Metabolism, Aluminum and magnesium containing antacidsProducts: ANCID 500MG, HYDROTALCIT RAT 500MG KTAPropofol
go.drugbank.com/drugs/DB00818ApprovedInvestigationalVet approvedPropofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. … Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries
Mixtures: Anesthesia S/I-60, Anesthesia S/I-40Categories: Hypnotics and SedativesNitrendipine
go.drugbank.com/drugs/DB01054ApprovedWithdrawnIt is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive. … Nitrendipine is a calcium channel blocker with marked vasodilator action.
Mixtures: ENEAS 10/20MG, ENEAS 10/20MGCategories: enalapril and nitrendipine, ACE Inhibitors and Calcium Channel BlockersDegarelix
go.drugbank.com/drugs/DB06699ApprovedInvestigationalDegarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. … Reduction in testosterone is important in treating men with advanced prostate cancer.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: Firmagon 120mg Powder and Solvent for Solution for Injection, Firmagon 80mg Powder and Solvent for Solution for InjectionEvolocumab
go.drugbank.com/drugs/DB09303ApprovedInvestigationalIt is approved for both homozygous and heterozygous familial cholesterolemia as an adjunct to other first-line therapies. … Evolocumab is designed to bind to PCSK9 and inhibit PCSK9 from binding to LDL receptors on the liver surface, resulting in more LDL receptors on the surface of the liver to remove LDL-C from the blood.
Categories: Amino Acids, Peptides, and ProteinsProducts: REPATHA SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 140MG/ML, Repatha Solution for Injection in Pre-filled Syringe 140mg/mL (evolocumab)Fondaparinux
go.drugbank.com/drugs/DB00569ApprovedInvestigationalangina (UA) and non-ST segment elevation myocardial infarction (NSTEMI); and in the management of ST segment elevation myocardial infarction (STEMI). … Once bound to heparin or HS, the anticoagulant activity of ATIII is potentiated by 1000-fold. Fondaparinux potentiates the neutralizing action of ATIII on activated Factor X 300-fold.
Categories: Blood and Blood Forming OrgansProducts: ARIXTRA ® 10MG /0.8 ML, ARIXTRA 5MG/0.4 ML S.S. ENJ. COZELTI ICEREN KULLANIMA HAZIR SIRINGA, 2 ADETThe Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria
smpdb.ca/view/SMP0002358DiseaseThis results in modulations of HIF-mediated hypoxia responses and alterations in gene expression through global epigenetic remodelling that may contribute to malignant transformation. … The compound 2-hydroxyglutarate is the product of gain-of-function mutations producing mutIDH1 and mutIDH2 in the cytosolic and mitochondrial isoforms of isocitrate dehydrogenase (IDH).
Lercanidipine
go.drugbank.com/drugs/DB00528ApprovedInvestigationalWithdrawnLercanidipine is a calcium channel blocker of the dihydropyridine class. It is sold under various commercial names including Zanidip.
Mixtures: ZANIPRESS 20MG/10MG, ZANIPRESS 20MG/10MGCategories: Angiotensin II receptor blockers (ARBs) and calcium channel blockers, valsartan and lercanidipine