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Displaying results 731 - 740 of 10000 in total
  1. Drug

    Opium

    go.drugbank.com/drugs/DB11130
    ApprovedIllicit

    Therefore, opium is a sticky brown resin obtained by collecting and drying the latex that exudes from the poppy pods. … It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: Papaver somniferum resin
  2. Drug

    Karaya gum

    go.drugbank.com/drugs/DB10535
    Approved

    Karaya gum allergenic extract is used in allergenic testing.

    Synonyms: Karaya resin, Sterculia resinCategories: Compounds used in a research, industrial, or household setting
  3. Drug

    Nemvaleukin alfa

    go.drugbank.com/drugs/DB18187
    Investigational

    Synonyms: Fusion protein comprised of a circularly-permuted interleukin-2 (IL-2) with the extracellular domain of IL-2 receptor alpha, 2 receptor .alpha.
  4. Target

    GABA(A) Receptor

    go.drugbank.com/bio_entities/BE0004797
    TargetHumans

    GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (By similarity) … GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response (By similarity).

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit alpha-2Synonyms: GABA(A) receptor subunit alpha-1, GABA(A) receptor subunit alpha-2
  5. Drug

    KB3305

    go.drugbank.com/drugs/DB06349
    Experimental

    KB3305 is an investigational liver selective antagonist for the glucocorticoid receptor, developed by Karo Bio for the treatment of Type 2 Diabetes.

    Synonyms: (4R)-4-((3S,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-DIHYDROXY-3-(2-(4-((8S,11R,13S,14S,17S)-17-HYDROXY-13-METHYL-3-OXO-17-PROP-1-YNYL-1,2,6,7,8,11,12,14,15,16-DECAHYDROCYCLOPENTA(A)PHENANTHREN-11-YL)-N-METHYL-ANILINO, 3.BETA.,5.BETA.,7.ALPHA.,12.ALPHA.)-7,12-DIHYDROXY-3-(2-((4-((11.BETA.,17.BETA.)-17-HYDROXY-3-OXO-17-(1-PROPYN-1-YL)ESTRA-4,9-DIEN-11-YL)PHENYL)METHYLAMINO)ETHOXY)CHOLAN-24-OIC ACID
  6. Target

    Biliverdin reductase A

    go.drugbank.com/bio_entities/BE0000741
    TargetEnzymeHumans

    Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666,

    Polypeptides: Biliverdin reductase ASynonyms: BVR A
  7. Target

    Apolipoprotein A-II

    go.drugbank.com/bio_entities/BE0000922
    TargetHumans

    May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism

    Polypeptides: Apolipoprotein A-IIFunction: apolipoprotein receptor binding
  8. Target

    Thromboxane-A synthase

    go.drugbank.com/bio_entities/BE0001893
    TargetHumans

    Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:11097184, PubMed:11297515, PubMed:22735388, … Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same

    Polypeptides: Thromboxane-A synthase
  9. Target

    Alpha-galactosidase A

    go.drugbank.com/bio_entities/BE0002422
    TargetEnzymeHumans

    Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome

    Polypeptides: Alpha-galactosidase ASynonyms: Alpha-D-galactosidase A
  10. Target

    Surface protein A

    go.drugbank.com/bio_entities/BE0002809
    TargetNeisseria meningitidis

    Polypeptides: Surface protein A