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Displaying results 7431 - 7440 of 10000 in total
  1. Target

    Voltage-dependent L-type calcium channel subunit beta-4

    go.drugbank.com/bio_entities/BE0002356
    TargetHumans

    The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibiti...

    Polypeptides: Voltage-dependent L-type calcium channel subunit beta-4Synonyms: Calcium channel voltage-dependent subunit beta 4
  2. Target

    Putative dehydrogenase/reductase SDR family member 4-like 1

    go.drugbank.com/bio_entities/BE0003983
    TargetHumans

    Putative oxidoreductase

    Polypeptides: Putative dehydrogenase/reductase SDR family member 4-like 1Synonyms: Short chain dehydrogenase/reductase family 25C member 4
  3. Drug

    Duloxetine

    go.drugbank.com/drugs/DB00476
    ApprovedInvestigational

    Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. … [L6454] It has since received approval for a variety of indications including the treatment of neuropathic pain, Generalized Anxiety disorder, osteoarthritis, and stress incontinence.

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: (3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine, (S)-duloxetine
  4. Drug

    Clonidine

    go.drugbank.com/drugs/DB00575
    ApprovedInvestigational

    [L7237,L54536,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.[L7237] … Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors.[A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD.

    Categories: Sympathomimetics in Glaucoma Therapy, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexSynonyms: 2,6-Dichloro-N-2-imidazolidinylidenebenzenamine, 2-((2,6-Dichlorophenyl)imino)imidazolidine
  5. Drug

    Mebendazole

    go.drugbank.com/drugs/DB00643
    ApprovedInvestigationalVet approved

    A benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. [PubChem]

    Mixtures: L-OMBRIX-DUET, L-OMBRIX-DUETCategories: Heterocyclic Compounds, 2-Ring
  6. Drug

    Hydroxyzine

    go.drugbank.com/drugs/DB00557
    ApprovedInvestigational

    Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties. … [A1257,A187589] It was first developed in 1955,[A189726] and has since remained a relatively common treatment for allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus

    Mixtures: DOLMARAL®Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  7. Pathway

    Acylcarnitine 3-Hydroxy-6-octenoylcarnitine

    smpdb.ca/view/SMP0123375
    Metabolic

    3-Hydroxy-6-octenoylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, 3-hydroxy-6-octenoyl-CoA reacts with L-carnitine to form 3-hydroxy-6-octenoylcarnitine. This reaction is catalyzed by carnitine O-palmitoyltransferase.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
  8. Pathway

    Acylcarnitine 6-hydroxynon-3-enoylcarnitine

    smpdb.ca/view/SMP0123422
    Metabolic

    6-hydroxynon-3-enoylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, 6-hydroxynon-3-enoyl-CoA reacts with L-carnitine to form 6-hydroxynon-3-enoylcarnitine. This reaction is catalyzed by carnitine O-palmitoyltransferase.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
  9. Pathway

    Acylcarnitine 6-Hydroxydec-3-enedioylcarnitine

    smpdb.ca/view/SMP0123880
    Metabolic

    6-Hydroxydec-3-enedioylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, 6-hydroxydec-3-enedioyl-CoA reacts with L-carnitine to form 6-hydroxydec-3-enedioylcarnitine. This reaction is catalyzed by carnitine O-palmitoyltransferase.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
  10. Pathway

    Acylcarnitine 6-Hydroxytrideca-8,10-dienoylcarnitine

    smpdb.ca/view/SMP0124125
    Metabolic

    6-Hydroxytrideca-8,10-dienoylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, 6-hydroxytrideca-8,10-dienoyl-CoA reacts with L-carnitine to form 6-hydroxytrideca-8,10-dienoylcarnitine.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more