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Displaying results 751 - 760 of 3387 in total
  1. Target

    Interferon alpha/beta receptor (IFNAR)

    go.drugbank.com/bio_entities/BE0010136
    TargetHumans

    Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:2153461 … Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity)

    Polypeptides: Interferon alpha/beta receptor 1, Interferon alpha/beta receptor 2Synonyms: IFN-alpha/beta receptor 1, IFN-alpha/beta receptor 2
  2. Target

    Interleukin-1 receptor-like 2

    go.drugbank.com/bio_entities/BE0010198
    TargetHumans

    Receptor for interleukin-36 (IL36A, IL36B and IL36G). … After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways

    Polypeptides: Interleukin-1 receptor-like 2Synonyms: IL-36 receptor, Interleukin-1 receptor-related protein 2
  3. Target

    Interleukin-7 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0010557
    TargetHumans

    Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP)

    Polypeptides: Interleukin-7 receptor subunit alphaSynonyms: IL-7 receptor subunit alpha
  4. Target

    Sphingosine 1-phosphate receptor 2

    go.drugbank.com/bio_entities/BE0012208
    TargetHumans

    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617, PubMed:25274307). … Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity).

    Polypeptides: Sphingosine 1-phosphate receptor 2Synonyms: S1P receptor 2, S1P receptor Edg-5
  5. Target

    N-formyl peptide receptor 2

    go.drugbank.com/bio_entities/BE0012843
    TargetHumans

    Differential signaling is also defined by receptor oligomerization state. … Pattern recognition G protein-coupled receptor (GPCR) that recognizes peptides with N-terminal formyl methionine, which are derived from invading pathogens or host mitochondria as pathogen or damage-associated

    Polypeptides: N-formyl peptide receptor 2Synonyms: LXA4 receptor, Lipoxin A4 receptor
  6. Drug

    Lufotrelvir

    go.drugbank.com/drugs/DB16514
    Investigational

    Once administered through intravenous infusion, the compound is cleaved into PF-00835231 to exert its anti-viral effects[L31718]. … Phase 1b studies are also exploring the safety and tolerability of PF-07304814 in COVID-19 patients who are hospitalized (NCT04535167).

  7. Drug

    Dimethicone

    go.drugbank.com/drugs/DB11074
    ApprovedInvestigational

    Dimethicone is a silicone oil that is also known as polydimethylsiloxane (PDMS). It has viscoelastic properties. Dimethicone is used as a surfactant, antifoaming agent, carminative in various products such as medical devices, food produc...

    Products: Mederma PM, PJ Bullet Capsuled
  8. Drug

    Castor oil

    go.drugbank.com/drugs/DB11113
    ApprovedNutraceuticalVet approved

    Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (Ricinus communis L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of DB02955, which represents up to 90% o...

  9. Drug

    Buntanetap

    go.drugbank.com/drugs/DB15317
    Investigational

    Buntanetap (previously known as Posiphen) is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease).

  10. Drug

    CT-011

    go.drugbank.com/drugs/DB05916
    Investigational

    It is directed against human PD-1 (programmed cell death 1; PDCD1), with immunomodulating and antitumor activities.