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Displaying results 7741 - 7750 of 10000 in total
  1. Pathway

    Acylcarnitine (3Z)-2-propylpent-3-enoylcarnitine

    smpdb.ca/view/SMP0123567
    Metabolic

    (3Z)-2-propylpent-3-enoylcarnitine is an acylcarnitine. … Once in the matrix, (3Z)-2-propylpent-3-enoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form (3Z)-2-propylpent-3-enoyl-CoA

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-palmitoyltransferase 2, mitochondrial
  2. Pathway

    Acylcarnitine (2E)-4-Hydroxytetradec-2-enoylcarnitine

    smpdb.ca/view/SMP0124157
    Metabolic

    (2E)-4-Hydroxytetradec-2-enoylcarnitine is an acylcarnitine. … -2-enoyl-CoA and L-carnitine. (2E)-4-Hydroxytetradec-2-enoyl-CoA then enters into the mitochondrial beta-oxidation pathway to form aceytl-CoA.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-palmitoyltransferase 2, mitochondrial
  3. Drug

    Propiverine

    go.drugbank.com/drugs/DB12278
    Approved

    Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB) [A32576]. … OAB has a negative impact on quality of life and may lead to leakage and inconvenient urinary accidents [L2327], [L2328].

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: MİCTONORM 5 MG KAPLI TABLET, 98 ADET, MICTONORM UNO 30 MG HARTK.
  4. Pathway

    2-Amino-3-Carboxymuconate Semialdehyde Degradation

    smpdb.ca/view/SMP0121131
    Metabolic

    An unknown protein forms a 2-aminomuconate deaminase which forms (3E)-2-oxohex-3-enedioate, and a second unknown protein forms a 2-aminomuconate reductase, which forms oxoadipic acid from (3E)-2-oxohex … to form 2-aminomuconic acid.

    Drugs: NADH · Flavin adenine dinucleotide
    Enzymes: 2-aminomuconic semialdehyde dehydrogenase, 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
  5. Pathway

    Acylcarnitine (2Z)-5-Hydroxydec-2-enedioylcarnitine

    smpdb.ca/view/SMP0123884
    Metabolic

    (2Z)-5-Hydroxydec-2-enedioylcarnitine is an acylcarnitine. … Once in the matrix, (2Z)-5-hydroxydec-2-enedioylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form (2Z)-5-hydroxydec-2-enedioyl-CoA

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-palmitoyltransferase 2, mitochondrial
  6. Drug

    Isavuconazonium

    go.drugbank.com/drugs/DB06636
    ApprovedInvestigational

    Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis … Isovuconazonium has excellent oral bioavailability, predictable pharmacokinetics, and a good safety profile, making it a reasonable alternative to its few other competitors on the market.

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP2B6 InducersProducts: CRESEMBA® 200 MG POLVO LIOFILIZADO ESTERIL PARA RECONSTITUIR, CRESEMBA ® CAPSULAS
  7. Drug

    Corifollitropin alfa

    go.drugbank.com/drugs/DB09066
    ApprovedInvestigational

    Corifollitropin alfa is produced by a method known as ‘recombinant DNA technology’. … In July 2014, Merck announced the receipt of a Complete Response Letter (CRL) from the U.S. FDA for its New Drug Application for this drug.

    Products: GONAL-F ® 300 UI (22 MCG)/0.5 ML INYECTOR (FOLITROPINA ALFA (R-HFSH)), GONAL-F ® INYECTOR 900 UI (66 MCG)/1.5 ML
  8. Drug

    Trastuzumab emtansine

    go.drugbank.com/drugs/DB05773
    ApprovedInvestigational

    Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent … T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-microtubule agent, DM1 (a maytansine derivative)--to produce cell cycle arrest and apoptosis.

    Synonyms: T-DM1Categories: HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors, P-glycoprotein substrates with a Narrow Therapeutic Index
  9. Drug

    Nifuroxazide

    go.drugbank.com/drugs/DB13855
    Investigational

    Mixtures: METRONIDAZOL/NIFUROXAZIDA 300 MG/100 MG., DIARSET NX® M CAPSULASCategories: Heterocyclic Compounds, 1-Ring
  10. Drug

    Zotepine

    go.drugbank.com/drugs/DB09225
    ApprovedWithdrawn

    Zotepine, with the formula (2-chloro-11-(2-dimethyl-amino-ethoxy)-dibenzo thiepin, is a neuroleptic drug. It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd. … [A31855] It has been used as an antipsychotic in Japan, India and some places in Europe like UK and Germany since 1980's.[A31857] Zotepine was never approved by the FDA.

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 3-RingProducts: ZOLEPTIL © 50 MG TABLETAS RECUBIERTAS.