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Displaying results 7761 - 7770 of 10000 in total
  1. Pathway

    Cardiolipin Biosynthesis CL(i-15:0/i-18:0/18:2(9Z,11Z)/18:2(9Z,11Z))

    smpdb.ca/view/SMP0464837
    Metabolic

    Third, the enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (PA or 1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the

    Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphate
    Enzymes: Phosphatidate cytidylyltransferase 2
  2. Drug

    Afoxolaner

    go.drugbank.com/drugs/DB11369
    ExperimentalVet approved

    Mixtures: Nexgard Spectra 9mg/2mg Chewable Tablets for Dogs 2-3.5kg, Nexgard Spectra 38mg/8mg Chewable Tablets for Dogs >7.5-15kgCategories: Heterocyclic Compounds, 1-Ring
  3. Drug

    Gemtuzumab ozogamicin

    go.drugbank.com/drugs/DB00056
    ApprovedInvestigational

    It is also indicated for the treatment of patients aged 2 years and older with CD33-positive AML who have experienced a relapse or who have not responded to initial treatment (refractory) [L941]. … Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheamicin per mole of antibody [FDA Label].

    Products: MYLOTARG 5 MG IV İNFÜZYONLUK ÇÖZELTİ HAZIRLAMADA KULLANILACAK KONSANTRE İÇİN TOZ, 1 FLAKON, MYLOTARG POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 5MG/VIAL
  4. Drug

    Brentuximab vedotin

    go.drugbank.com/drugs/DB08870
    ApprovedInvestigational

    Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). … [L1737] The ECHELON-1 study results demonstrated superior efficacy of the drug combined with a chemotherapy regimen compared to the previous standard of care.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: ADCETRIS 50 MG IV INFÜZYONLUK ÇÖZELTI KONSANTRESI IÇIN TOZ IÇEREN FLAKON ,FLAKON, 1 ADET, ADCETRIS 50 MG (POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION)
  5. Drug

    Enfortumab vedotin

    go.drugbank.com/drugs/DB13007
    ApprovedInvestigational

    [L10836] It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protease-cleavable … [L10836] It is similar to [brentuximab vedotin], another antibody conjugated with MMAE that targets CD-30 instead of Nectin-4.

    Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: PADCEV 20 MG İNFÜZYONLUK ÇÖZELTİ HAZIRLAMADA KULLANILACAK KONSANTRE İÇİN TOZ , 1 ADET, PADCEV 30 MG İNFÜZYONLUK ÇÖZELTİ HAZIRLAMADA KULLANILACAK KONSANTRE İÇİN TOZ , 1 ADET
  6. Pathway

    Acylcarnitine (2Z)-6-hydroxynon-2-enoylcarnitine

    smpdb.ca/view/SMP0123420
    Metabolic

    (2Z)-6-hydroxynon-2-enoylcarnitine is an acylcarnitine. … Once in the matrix, (2Z)-6-hydroxynon-2-enoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form (2Z)-6-hydroxynon-2-enoyl-CoA

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-palmitoyltransferase 2, mitochondrial
  7. Pathway

    Acylcarnitine (3Z)-2-propylpent-3-enoylcarnitine

    smpdb.ca/view/SMP0123567
    Metabolic

    (3Z)-2-propylpent-3-enoylcarnitine is an acylcarnitine. … Once in the matrix, (3Z)-2-propylpent-3-enoylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form (3Z)-2-propylpent-3-enoyl-CoA

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-palmitoyltransferase 2, mitochondrial
  8. Pathway

    Acylcarnitine (2E)-4-Hydroxytetradec-2-enoylcarnitine

    smpdb.ca/view/SMP0124157
    Metabolic

    (2E)-4-Hydroxytetradec-2-enoylcarnitine is an acylcarnitine. … -2-enoyl-CoA and L-carnitine. (2E)-4-Hydroxytetradec-2-enoyl-CoA then enters into the mitochondrial beta-oxidation pathway to form aceytl-CoA.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-palmitoyltransferase 2, mitochondrial
  9. Pathway

    2-Amino-3-Carboxymuconate Semialdehyde Degradation

    smpdb.ca/view/SMP0121131
    Metabolic

    An unknown protein forms a 2-aminomuconate deaminase which forms (3E)-2-oxohex-3-enedioate, and a second unknown protein forms a 2-aminomuconate reductase, which forms oxoadipic acid from (3E)-2-oxohex … to form 2-aminomuconic acid.

    Drugs: NADH · Flavin adenine dinucleotide
    Enzymes: 2-aminomuconic semialdehyde dehydrogenase, 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
  10. Pathway

    Acylcarnitine (2Z)-5-Hydroxydec-2-enedioylcarnitine

    smpdb.ca/view/SMP0123884
    Metabolic

    (2Z)-5-Hydroxydec-2-enedioylcarnitine is an acylcarnitine. … Once in the matrix, (2Z)-5-hydroxydec-2-enedioylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form (2Z)-5-hydroxydec-2-enedioyl-CoA

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Carnitine O-palmitoyltransferase 2, mitochondrial