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Macitentan
go.drugbank.com/drugs/DB08932ApprovedInvestigational[L35890] It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] in part due to its lower risk of hepatotoxicity. … A combination product (Opsynvi) comprising macitentan and [tadalafil] was approved in Canada in October 2021 for the treatment of PAH.[L39105] It was subsequently approved by the FDA in March 2024.
Mixtures: OPSYNVI® (MACITENTAN/TADALAFILO) 10MG/40 MG TABLETAS RECUBIERTASCategories: macitentan and tadalafilChlorhexidine
go.drugbank.com/drugs/DB00878ApprovedInvestigationalVet approvedWithdrawn[L11518,L11512,A190453] Chlorhexidine was developed in the UK by Imperial Chemical Industries in the early 1950s[A190474] and was introduced to the US in the 1970s. … [A190417] The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings and two biguanide groups joined by a central hexamethylene chain.
Mixtures: easyangin Mentholgeschmack 5mg/1mg Lutschtabletten, BEPANTHEN PLUS 50 MG/5MG KREM, 30 GCategories: Biguanides and Amidines, Alimentary Tract and MetabolismMontelukast
go.drugbank.com/drugs/DB00471ApprovedInvestigationalMontelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. … worldwide via millions of prescriptions annually and has since become available as a generic and as a brand name product.
Mixtures: BROCRIPTIN® 5MG/2.5MGCategories: Hormones, Hormone Substitutes, and Hormone AntagonistsClofarabine
go.drugbank.com/drugs/DB00631ApprovedInvestigationalIt is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. … Its potential use in acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) has been investigated.
Categories: Antineoplastic and Immunomodulating Agents, Nucleic Acids, Nucleotides, and NucleosidesProducts: CLOFAZIC® 20MG/20ML, METISA® 1MG /MLRurioctocog alfa pegol
go.drugbank.com/drugs/DB16007ApprovedInvestigational[L40119] Rurioctocog alfa pegol is a covalent conjugate of [octocog alfa], which is a recombinant factor VIII produced by recombinant DNA technology from a Chinese hamster ovary cell line. … Factor VIII is an essential protein involved in normal blood clotting; thus, a deficient level of functional factor VIII is associated with an elevated risk for excessive bleeding caused by spontaneous
Categories: Amino Acids, Peptides, and ProteinsProducts: ADYNOVATE 1500IU Powder and Solvent for Solution for Injection, ADYNOVATE 2000IU Powder and Solvent for Solution for InjectionCapsaicin
go.drugbank.com/drugs/DB06774ApprovedInvestigationalCapsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements … The most recent capsaicin FDA approval was Qutenza, an 8% capsaicin patch dermal-delivery system, indicated for neuropathic pain associated with post-herpetic neuralgia.
Mixtures: Satohap Cool and Hot Pads, DFS 75mg DR/MS 25%/MENTH 6%/CAP 0.025% PAKCategories: Basic Lotions and Liniments, Capsaicin and Similar AgentsFlubendazole
go.drugbank.com/drugs/DB08974ApprovedInvestigationalWithdrawnFlubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe.
Categories: Antiparasitic Products, Insecticides and RepellentsProducts: FLUVERMAL SUSPENSION 20MG/ML, HELMIN EX SUSPENSION 100MG/5MLClarithromycin
go.drugbank.com/drugs/DB01211ApprovedInvestigationalClarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. … Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process.
Mixtures: Lansoprazole, Amoxicillin, and Clarithromycin, Lansoprazole, Amoxicillin and ClarithromycinCategories: Alimentary Tract and Metabolism, Erythromycin and similarsClove oil
go.drugbank.com/drugs/DB11338ApprovedNutraceuticalClove oil is obtained by extraction from the dried flower buds of the clove plant. Traditionally, it has been used as a flavouring spice in foods, or as a fragrance. … Clove is native of Indonesia but is now cultured in several parts of the world, including Brazil in the state of _Bahia_.
Synonyms: Clove bud oil, Ding xiang bud oilDaratumumab
go.drugbank.com/drugs/DB09331ApprovedInvestigationalDaratumumab is an immunoglobulin G1 kappa monoclonal antibody developed by Janssen and Genmab. … This approval was based on results from the Phase 3 PERSEUS study, which demonstrated significant improvement in progression-free survival and higher rates of minimal residual disease (MRD) negativity
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: Darzalex 20mg/mL Concentrate for Solution for Infusion, DARZALEX CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/5ML