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Displaying results 7881 - 7890 of 8412 in total

Drug
Telithromycin
go.drugbank.com/drugs/DB00976
Approved
Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inhibitors
Drug
Lomefloxacin
go.drugbank.com/drugs/DB00978
Approved
Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inhibitors
Drug
Perhexiline
go.drugbank.com/drugs/DB01074
Approved
Perhexiline is a coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 Substrates
Drug
Proguanil
go.drugbank.com/drugs/DB01131
Approved
Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofo...
Synonyms: 1-(p-Chlorophenyl)-5-isopropylbiguanideCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 Substrates
Drug
Ethambutol
go.drugbank.com/drugs/DB00330
ApprovedInvestigational
Ethambutol is a bacteriostatic agent indicated alongside medications such as isoniazid, rifampin, and pyrazinamide in the treatment of pulmonary tuberculosis. Ethambutol was first described in the literature in 1961. It was developed out...
Synonyms: (+)-2,2'-(ethylenediimino)di-1-butanolCategories: P-glycoprotein substrates, Cytochrome P-450 CYP1A2 Inhibitors
Drug
Dydrogesterone
go.drugbank.com/drugs/DB00378
ApprovedInvestigationalWithdrawn
A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
Drug
Nisoldipine
go.drugbank.com/drugs/DB00401
Approved
Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in s...
International brands: Di Yi XinCategories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
Drug
Cisplatin
go.drugbank.com/drugs/DB00515
ApprovedInvestigational
Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lympho...
Categories: Cytochrome P-450 CYP2B6 Inhibitors, Cytochrome P-450 CYP2C9 InhibitorsProducts: BLASTOLEM RU, BLASTOLEM RU 10 MG SOLUCION INYECTABLE
Drug
Sulfamethizole
go.drugbank.com/drugs/DB00576
ApprovedVet approved
A sulfathiazole antibacterial agent.
Categories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 Enzyme Inhibitors
Drug
Nizatidine
go.drugbank.com/drugs/DB00585
Approved
A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.
Categories: P-glycoprotein substratesProducts: Axid Ar, Nu-nizatidine