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Displaying results 781 - 790 of 10000 in total
  1. Target

    Fibroblast growth factor receptor

    go.drugbank.com/bio_entities/BE0010259
    TargetHumans

    FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. … Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and

    Polypeptides: Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2Synonyms: Keratinocyte growth factor receptor, Basic fibroblast growth factor receptor 1
  2. Target

    Opioid growth factor receptor

    go.drugbank.com/bio_entities/BE0010541
    TargetHumans

    Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation

    Polypeptides: Opioid growth factor receptorSynonyms: Zeta-type opioid receptor
  3. Target

    Toll-like receptor 3

    go.drugbank.com/bio_entities/BE0010688
    TargetHumans

    Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is acti...

    Polypeptides: Toll-like receptor 3
  4. Target

    Gastrin-releasing peptide receptor

    go.drugbank.com/bio_entities/BE0012984
    TargetHumans

    Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761).

    Polypeptides: Gastrin-releasing peptide receptorSynonyms: GRP-preferring bombesin receptor
  5. Target

    Leukemia inhibitory factor receptor

    go.drugbank.com/bio_entities/BE0013220
    TargetHumans

    Functions as a membrane-bound signal-transducing subunit either in complex with IL6ST/gp130 or as part of the ciliary neurotrophic factor receptor (CNTFR) complex composed by CNTFR, IL6ST/gp130 and LIFR … initiated either by binding directly to cytokines, such as OSM or LIF or CTF1, or through the binding of other cytokines, like CNTF, CLCF1 or the heterodimeric complex CRLF1-CLCF1 to the non-signaling receptor

    Polypeptides: Leukemia inhibitory factor receptorSynonyms: LIF receptor
  6. Target

    Nuclear receptor ROR-gamma

    go.drugbank.com/bio_entities/BE0013275
    TargetHumans

    Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence.

    Polypeptides: Nuclear receptor ROR-gammaSynonyms: Nuclear receptor RZR-gamma, RAR-related orphan receptor C
  7. Target

    Interleukin-17 receptor C

    go.drugbank.com/bio_entities/BE0017016
    TargetHumans

    Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). … Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971).

    Polypeptides: Interleukin-17 receptor CSynonyms: IL-17 receptor C, Interleukin-17 receptor homolog
  8. Target

    Interleukin-17 receptor E

    go.drugbank.com/bio_entities/BE0017393
    TargetHumans

    Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling.

    Polypeptides: Interleukin-17 receptor ESynonyms: IL-17 receptor E
  9. Target

    Lysophosphatidic acid receptor 3

    go.drugbank.com/bio_entities/BE0020529
    TargetHumans

    Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer.

    Polypeptides: Lysophosphatidic acid receptor 3Synonyms: LPA receptor 3, Lysophosphatidic acid receptor Edg-7
  10. Drug

    Ergocalciferol

    go.drugbank.com/drugs/DB00153
    ApprovedInvestigationalNutraceutical

    [T577] The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets. … [T580] Ergocalciferol is considered the first vitamin D analog and is differentiated from [cholecalciferol] by the presence of a double bond between C22 and C23 and the presence of a methyl group at

    Mixtures: Se-Natal, Swical-energy 3e AgeSynonyms: (3β,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol, (5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-ol