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Displaying results 71 - 80 of 124 in total
  1. Pathway

    Steroid Biosynthesis

    smpdb.ca/view/SMP0000023
    Metabolic

    This compound is then reduced to mevalonic acid via the enzyme HMG-CoA reductase. … The resulting mevalonic acid (or mevalonate) is then phosphorylated by the enzyme known as mevalonate kinase to form mevalonate-5-phosphate, which is then phosphorylated again by phosphomevalonate kinase

    Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 more
    Enzymes: Lysosomal acid lipase/cholesteryl ester hydrolase
  2. Pathway

    Wolman Disease

    smpdb.ca/view/SMP0000511
    Disease

    Wolman's Disease results from severely reduced levels of the enzyme lysosomal acid lipase/acid cholesteryl ester hydrolase. … Lysosomal acid lipase/acid cholesteryl ester hydrolase (LAL/ACEH) plays an important role in cellular processing of plasma lipoproteins and thus contributes to both the homeostatic control of

    Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 more
    Enzymes: Lysosomal acid lipase/cholesteryl ester hydrolase
  3. Pathway

    Pravastatin Action Pathway

    smpdb.ca/view/SMP0000089
    Drug action

    HMG-CoA reductase is the enzyme responsible for the conversion of HMG-CoA to mevalonic acid, the rate-limiting step of cholesterol synthesis by this pathway. … Pravastatin bears a chemical resemblance to the reduced HMG-CoA reaction intermediate that is formed during catalysis.

    Drugs: Cholecalciferol · ATP · Pravastatin · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 more
    Enzymes: Lysosomal acid lipase/cholesteryl ester hydrolase
  4. Pathway

    Rosuvastatin Action Pathway

    smpdb.ca/view/SMP0000092
    Drug action

    This enzyme is typically responsible for the conversion of HMG-CoA to mevalonic acid, the third and rate-limiting step of cholesterol, LDL and VLDL synthesis.

    Drugs: Cholecalciferol · ATP · Rosuvastatin · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 more
    Enzymes: Lysosomal acid lipase/cholesteryl ester hydrolase
  5. Pathway

    Cerivastatin Action Pathway

    smpdb.ca/view/SMP0000111
    Drug action

    HMG-CoA reductase is the enzyme responsible for the conversion of HMG-CoA to mevalonic acid, the rate-limiting step of cholesterol synthesis by this pathway. … Cerivastatin bears a chemical resemblance to the reduced HMG-CoA reaction intermediate that is formed during catalysis.

    Drugs: Cholecalciferol · ATP · Cerivastatin · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 more
    Enzymes: Lysosomal acid lipase/cholesteryl ester hydrolase
  6. Pathway

    Alendronate Action Pathway

    smpdb.ca/view/SMP0000095
    Drug action

    Alendronate (also known as alendronic acid) is a type of bisphosphonate medication with nitrogen that can inhibit FPP synthase, which can block the pathway that produce geranyl-PP and farnesyl pyrophosphate

    Drugs: Cholecalciferol · ATP · Alendronic acid · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 more
    Enzymes: Lysosomal acid lipase/cholesteryl ester hydrolase
  7. Pathway

    Zoledronate Action Pathway

    smpdb.ca/view/SMP0000107
    Drug action

    Zoledronate (also named zoledronic acid, Zometa or Reclast) is a type of medication that used to treat numbers of bone diseases because of its affinity for hydroxyapatite.

    Drugs: Cholecalciferol · ATP · Zoledronic acid · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 more
    Enzymes: Lysosomal acid lipase/cholesteryl ester hydrolase
  8. Pathway

    Desmosterolosis

    smpdb.ca/view/SMP0000386
    Disease

    Desmosterolosis is caused by a mutation in the DHCR24 gene, which codes for the enzyme 24-dehydrocholesterol reductase, which catalyzes the reduction of the delta-24 double bond of sterol intermediates. A defect in 24-dehydrocholesterol ...

    Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 more
    Enzymes: Lysosomal acid lipase/cholesteryl ester hydrolase
  9. Pathway

    CHILD Syndrome

    smpdb.ca/view/SMP0000387
    Disease

    CHILD Syndrome, (Congenital Hemidysplasia with Icthyosiform Erythroderma and Limb Defects; Ichthyosiform Eruthroderma, Unilateral, with Epsilateral Malformations, Especially Absence Deformity of Limbs) is caused by a mutation in the gene...

    Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 more
    Enzymes: Lysosomal acid lipase/cholesteryl ester hydrolase
  10. Pathway

    Hyper-IgD Syndrome

    smpdb.ca/view/SMP0000509
    Disease

    Hyperimmunoglobulinemia D syndrome, or HIDS, is a condition characterized by fevers that come and go, usually lasting 3-7 days, and other various symptoms such as rashes, vomiting, diarrhea and aphthous ulcers. These are usually noticed ...

    Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 more
    Enzymes: Lysosomal acid lipase/cholesteryl ester hydrolase