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Methotrexate
go.drugbank.com/drugs/DB00563ApprovedInvestigational[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients … [A180322] Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma
Synonyms: 4-amino-N(10)-methylpteroylglutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acidProducts: INJ METHOTREXATE CS 50MG IN 2ML, INJ METHOTREXATE CS 1000MG IN 10MLErythropoietin
go.drugbank.com/drugs/DB00016ApprovedInvestigationalEpoetin alfa (Epoge) was developed by Amgen Inc. in 1983 as the first rhEPO commercialized in the United States, followed by other alfa and beta formulations. … Erythropoietin (EPO) is a growth factor produced in the kidneys that stimulates the production of red blood cells.
Products: AIMAPEX 4000 IU/ML IN PREFILLED SYRINGE, HEMA-PLUS 1000 IU IN 0.25 ML PREFILLED SYRINGEMagnesium sulfate
go.drugbank.com/drugs/DB00653ApprovedInvestigationalVet approvedA small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. … It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions.
Mixtures: Magnesium Sulfate In 5% Dextrose Inj(20mg/ml), Multiple Electrolyte Additive InjSynonyms: magnesium(II) sulfateFatty Acid Elongation in Mitochondria
smpdb.ca/view/SMP0000054MetabolicIn liver and kidney fatty acid elongation operates best in the presence of both NADH and NADPH, whereas in heart and skeletal muscle, only NADH is required. … Mitochondrial elongation may result in fatty acids up to C16 in length. Fatty acid elongation in mitochondria is essentially the reverse of beta-oxidation for fatty acid oxidation.
Insulin human
go.drugbank.com/drugs/DB00030ApprovedInvestigationalAfrezza does not currently have Health Canada or European Medicines Agency approval for marketing in Canada or the EU. … Insulin is an important treatment in the management of Type 1 Diabetes (T1D) which is caused by an autoimmune reaction that destroys the beta cells of the pancreas, resulting in the body not being able
Mixtures: Humulin 10/90 Inj, Humulin 10/90 InjCategories: Drugs Used in DiabetesIndium In-111 pentetate Drug Metabolism
smpdb.ca/view/SMP0130595MetabolicIndium In-111 pentetate passes through the liver and is then excreted from the body mainly through the kidney. … Indium In-111 pentetate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Indium In-111 pentetateRabies immune globulin, human
go.drugbank.com/drugs/DB11603ApprovedIMOGAM Rabies Pasteurized should be administered promptly after exposure, in conjunction with rabies vaccine. … IMOGAM Rabies Pasteurized is indicated for post-exposure prophylaxis in persons suspected of exposure to rabies, who have not previously received a complete immunization regimen with a cell culture produced
Products: Rabipur Pulver und Lösungsmittel zur Herstellung einer Injektionslösung in einer Fertigspritze, EQUIRAB 1000 IU/5ML IM/SC ÇÖZELTI IÇEREN FLAKON, 1 ADETFc Epsilon Receptor I Signaling in Mast Cells
smpdb.ca/view/SMP0000358SignalingThe release of these compounds results in the inflammatory response. … Fc epsilon receptor 1 (Fc epsilon RI) is a high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotope involved in allergies.
Atropine
go.drugbank.com/drugs/DB00572ApprovedInvestigationalVet approvedOral atropine is only available in combination products. … [A251660] Atropine is a relatively inexpensive drug and is included in the World Health Organization List of Essential Medicines.[A251675]
Products: Atropin Accord 0,1 mg/ml Injektionslösung in einer Fertigspritze, Atropinsulfat Aguettant 0,1 mg/ml Injektionslösung in FertigspritzeGolimumab
go.drugbank.com/drugs/DB06674ApprovedInvestigationaltreatment in patients with active psoriatic arthritis (PsA), (iii) as a single agent in patients with active ankylosing spondylitis (AS), and (iv) as a single agent in patients with moderate to severe … Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients with moderate to severe active rheumatoid arthritis (RA), (ii) alone or as an adjunct to methotrexate
Products: SIMPONI 100MG ILO IN FER, SIMPONI 50MG ILO IN FER