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Memantine
go.drugbank.com/drugs/DB01043ApprovedInvestigationalIn December 2013, the G8 dementia summit concluded that dementia should be considered a global priority with the objective of developing a cure or a disease-modifying therapy by the year 2025 [L5953, F4366 … Memantine blocks the effects of glutamate, a neurotransmitter in the brain that leads to neuronal excitability and excessive stimulation in Alzheimer's Disease [T556].
Mixtures: DEMAX 5 MG+10 MG+15 MG+20 MG TEDAVİ BAŞLANGIÇ PAKETİ, DEMAX 5 MG+10 MG+15 MG+20 MG TEDAVİ BAŞLANGIÇ PAKETİCategories: Cytochrome P-450 CYP2A6 Inhibitors, Cytochrome P-450 CYP2B6 InhibitorsOrlistat
go.drugbank.com/drugs/DB01083ApprovedInvestigationalIt was approved by the FDA for use in combination with a reduced-calorie diet in 1999. … [A229928] Orlistat is a lipase inhibitor used in the treatment of obesity that works by inhibiting fat-metabolizing enzymes.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersProducts: ORALLI LW®, ORLISTAT 120 MGIrinotecan
go.drugbank.com/drugs/DB00762ApprovedInvestigationalIrinotecan is a topoisomerase inhibitor used for chemotherapy. It is a water-soluble analogue of [camptothecin], which is extracted from the Chinese tree _Camptotheca acuminate_. … [L50186] The active metabolite SN-38 is also a potent inhibitor of DNA topoisomerase I.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic IndexProducts: DARITEX-A, IRINOX 150 MG/7 ML İNFÜZYON İÇİN KONSANTRE ÇÖZELTİ İÇEREN FLAKON, 10 ADETRoxithromycin
go.drugbank.com/drugs/DB00778ApprovedInvestigationalWithdrawnIt is marketed in Australia as a treatment for respiratory tract, urinary and soft tissue infections. … Roxithromycin is a semi-synthethic macrolide antibiotic that is structurally and pharmacologically similar to [erythromycin], [azithromycin], or [clarithromycin].
International brands: Roxl-150, Roxy-150Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InhibitorsBudesonide
go.drugbank.com/drugs/DB01222ApprovedInvestigationalBudesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis. … [L10598] It is also available in a combination product with [formoterol].[L10619]
Mixtures: FIXCORT 4.5/160 MG CAPSAIR INHALASYON İÇİN TOZ İÇEREN KAPSÜL, 120 ADET, FIXCORT 9/320 MG CAPSAIR INHALASYON İÇİN TOZ İÇEREN KAPSÜL, 120 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 InducersPhenobarbital
go.drugbank.com/drugs/DB01174ApprovedInvestigationalA barbituric acid derivative that acts as a nonselective central nervous system depressant.
Mixtures: PIROFEN 200 MG/15 MG SUPPOZITUAR, 50 ADET, PIROFEN 200 MG/15 MG SUPPOZITUAR, 10 ADETCategories: Cytochrome P-450 CYP2C18 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic IndexTapentadol
go.drugbank.com/drugs/DB06204ApprovedInvestigationalTapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesProducts: PALEXIS® RETARD 150 MG, Nucynta ER Tablets 150 mgGentamicin
go.drugbank.com/drugs/DB00798ApprovedInvestigationalVet approvedGentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. … [A234359,A234364] Although gentamicin is well-established and may be used in a variety of clinical applications, it is also associated with severe adverse effects including nephrotoxicity and ototoxicity
Mixtures: BELOGENT %0,05+%0,1 KREM, 15 G, BELOGENT %0,05+%0,1 MERHEM, 15 GCategories: OCT2 Substrates with a Narrow Therapeutic Index, Drugs that are Mainly Renally Excreted with a Narrow Therapeutic IndexD-glucose
go.drugbank.com/drugs/DB01914ApprovedInvestigationalVet approvedL-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative. … Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants.
Mixtures: PHYSIONEAL 40 DEXTROSE SOLUTION 1.5% w/v/15.0 mg/ml, TEOSEL 200 MG IV İNFÜZYONLUK ÇÖZELTİ (100 ML SETLI)Categories: Compounds used in a research, industrial, or household settingCarbamazepine
go.drugbank.com/drugs/DB00564ApprovedInvestigationalCarbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, ...
Categories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic IndexProducts: TIMONIL 150 RETARD, Tegretol Chewtabs 100 mg