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Irinotecan
go.drugbank.com/drugs/DB00762ApprovedInvestigationalIrinotecan is a topoisomerase inhibitor used for chemotherapy. It is a water-soluble analogue of [camptothecin], which is extracted from the Chinese tree _Camptotheca acuminate_. … [L50186] The active metabolite SN-38 is also a potent inhibitor of DNA topoisomerase I.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic IndexProducts: DARITEX-A, IRINOX 150 MG/7 ML İNFÜZYON İÇİN KONSANTRE ÇÖZELTİ İÇEREN FLAKON, 10 ADETRoxithromycin
go.drugbank.com/drugs/DB00778ApprovedInvestigationalWithdrawnIt is marketed in Australia as a treatment for respiratory tract, urinary and soft tissue infections. … Roxithromycin is a semi-synthethic macrolide antibiotic that is structurally and pharmacologically similar to [erythromycin], [azithromycin], or [clarithromycin].
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InhibitorsInternational brands: Roxl-150, Roxy-150Tapentadol
go.drugbank.com/drugs/DB06204ApprovedInvestigationalTapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesProducts: PALEXIS® RETARD 150 MG, Nucynta ER Tablets 150 mgBudesonide
go.drugbank.com/drugs/DB01222ApprovedInvestigationalBudesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis. … [L10598] It is also available in a combination product with [formoterol].[L10619]
Mixtures: FIXCORT 4.5/160 MG CAPSAIR INHALASYON İÇİN TOZ İÇEREN KAPSÜL, 120 ADET, FIXCORT 9/320 MG CAPSAIR INHALASYON İÇİN TOZ İÇEREN KAPSÜL, 120 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 InducersAlprostadil
go.drugbank.com/drugs/DB00770ApprovedInvestigationalAlprostadil is a chemically-identical synthetic form of prostaglandin E1 (PGE1), a potent vasodilator produced endogenously. … This drug causes vasodilation by directly affecting vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth.
Synonyms: (13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate, 11α,15α-dihydroxy-9-oxo-13-trans-prostenoic acidProducts: PROSTAVASIN 20 MCG I.A/ I.V INFÜZYON IÇIN KURU TOZ IÇEREN AMPUL, 15 ADET, CAVERJECT POWDER FOR INJECTION 10 mcg/mlOrlistat
go.drugbank.com/drugs/DB01083ApprovedInvestigationalIt was approved by the FDA for use in combination with a reduced-calorie diet in 1999. … [A229928] Orlistat is a lipase inhibitor used in the treatment of obesity that works by inhibiting fat-metabolizing enzymes.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersProducts: ORALLI LW®, ORLISTAT 120 MGPhenobarbital
go.drugbank.com/drugs/DB01174ApprovedInvestigationalA barbituric acid derivative that acts as a nonselective central nervous system depressant.
Mixtures: PIROFEN 200 MG/15 MG SUPPOZITUAR, 50 ADET, PIROFEN 200 MG/15 MG SUPPOZITUAR, 10 ADETCategories: Cytochrome P-450 CYP2C18 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic IndexCapecitabine
go.drugbank.com/drugs/DB01101ApprovedInvestigationalCapecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Categories: Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesProducts: XELODA 150 MG 60 LAK TABLET, CAPECITABIN AL 150 MG FTAD-glucose
go.drugbank.com/drugs/DB01914ApprovedInvestigationalVet approvedL-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative. … Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants.
Mixtures: PHYSIONEAL 40 DEXTROSE SOLUTION 1.5% w/v/15.0 mg/ml, TEOSEL 200 MG IV İNFÜZYONLUK ÇÖZELTİ (100 ML SETLI)Categories: Compounds used in a research, industrial, or household settingKetorolac
go.drugbank.com/drugs/DB00465ApprovedInvestigational[L6520] Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.[L6511] … Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.
Mixtures: Ixoba M, Ketorocaine L KitCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Substrates