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De Novo Triacylglycerol Biosynthesis TG(i-24:0/8:0/20:0)
smpdb.ca/view/SMP0042807MetabolicTriglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. … (Wikipedia) De novo biosynthesis of triglycerides is also known as the phosphatidic acid pathway, and it is mainly associated with the liver and adipose tissue.
Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126292Drug action, and rest-related cramps in the lower extremities. … Some side effects of using diltiazem may include dizziness, flushing, headache, and weakness.
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferaseMersalyl
go.drugbank.com/drugs/DB09338ExperimentalMersalyl is the sodium salt form of mersalyl acid, a mercurial diuretic. It is an outdated drug, and its approval has been discontinued by the FDA. … The sodium salt of a mercury-containing derivative of salicylamide, was formerly used (often in combination with theophylline) to treat edema, due to its powerful diuretic properties [L1577].
Simeprevir
go.drugbank.com/drugs/DB06290ApprovedWithdrawnAccording to 2017 American Association for the Study of Liver Diseases (AASLD) and 2015 consensus guidelines from the Canadian Association for the Study of the Liver (CASL), simeprevir can be used as first-line … Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection.
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsCoVac-1
go.drugbank.com/drugs/DB16429InvestigationalSponsored by the University Hospital Tuebingen in Germany, CoVac-1 is a multi-peptide COVID-19 vaccine candidate created from HLA class I and HLA-DR T-cell epitopes of the S-protein[A226588]. … is being investigated in the clinical trial NCT04546841 (Safety and Immunogenicity Trial of Multi-peptide Vaccination to Prevent COVID-19 Infection in Adults (pVAC))[L30428] and aims to induce broad T-cell
Bisegliptin
go.drugbank.com/drugs/DB06127InvestigationalIt is an orally active, dipeptidyl peptidase-IV (DPPIV) inhibitor which lowers blood glucose levels by blocking the degradation of the hormone GLP-1 thereby stimulating glucose-dependent insulin secretion … Bisegliptin is a compound for the treatment of type 2 diabetes.
Uridine diphosphate glucose
go.drugbank.com/drugs/DB01861ExperimentalServes as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and glucuronic acid. … A key intermediate in carbohydrate metabolism.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 5'-Diphosphoglucose, Uridine-5'-DiphosphoglucoseAfelimomab
go.drugbank.com/drugs/DB04956ExperimentalAfelimomab (also known as Fab 2 or MAK 195F) is an anti-TNF-α monoclonal antibody. Administration of 195F reduces the concentration of interleukin-6 in patients with sepsis.
Interferon alfa-2b
go.drugbank.com/drugs/DB00105ApprovedInvestigationalIt is used extensively as an antiviral or antineoplastic agent. … A type I interferon consisting of 165 amino acid residues with arginine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes.
Mixtures: Intron A, Intron ACategories: Interferon Type I, Cytochrome P-450 CYP1A2 InhibitorsSulfaphenazole
go.drugbank.com/drugs/DB06729ApprovedSulfaphenazole is a sulfonamide antibacterial.
Categories: Cytochrome P-450 CYP2B6 Inhibitors, Heterocyclic Compounds, 1-RingSynonyms: N(1)-(1-phenylpyrazol-5-yl)sulfanilamide, N'-(1-phenylpyrazol-5-yl)sulfanilamide