Search

Displaying results 821 - 830 of 10000 in total
  1. Target

    Galectin-2

    go.drugbank.com/bio_entities/BE0003247
    TargetHumans

    This protein binds beta-galactoside. Its physiological function is not yet known

    Synonyms: S-Lac lectin 2
  2. Target

    Aldo-keto reductase family 1 member A1

    go.drugbank.com/bio_entities/BE0004352
    TargetEnzymeHumans

    Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins (PubMed:30538128). … Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione (PubMed:31649033). Displays no reductase activity towards retinoids (By similarity)

    Synonyms: S-nitroso-CoA reductase
  3. Target

    Nitric oxide synthase, inducible

    go.drugbank.com/bio_entities/BE0000005
    TargetEnzymeHumans

    Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). … As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity

    Synonyms: Peptidyl-cysteine S-nitrosylase NOS2
  4. Target

    ATP-binding cassette sub-family C member 1

    go.drugbank.com/bio_entities/BE0000785
    TargetTransporterHumans

    Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. … Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (PubMed:9426231).

    Synonyms: Glutathione-S-conjugate-translocating ATPase ABCC1Function: ABC-type glutathione S-conjugate transporter activity
  5. Target

    RalA-binding protein 1

    go.drugbank.com/bio_entities/BE0004770
    TransporterHumans

    Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral...

    Synonyms: Dinitrophenyl S-glutathione ATPaseFunction: ABC-type glutathione S-conjugate transporter activity
  6. Target

    NACHT, LRR and PYD domains-containing protein 3

    go.drugbank.com/bio_entities/BE0010347
    TargetHumans

    Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:1840367...

    Polypeptides: NACHT, LRR and PYD domains-containing protein 3
  7. Drug

    Janagliflozin

    go.drugbank.com/drugs/DB16209
    Investigational

    Janagliflozin is under investigation in clinical trial NCT03851432 (Janagliflozin Treat Type 2 Diabetes Mellitus (T2DM) Inadequately Controlled With Metformin).

  8. Target

    Cytochrome P450 2C8

    go.drugbank.com/bio_entities/BE0002887
    TargetEnzymeHumans

    A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576, PubMed:7574697). Mecha...

    Synonyms: S-mephenytoin 4-hydroxylase
  9. Drug

    Gabapentin

    go.drugbank.com/drugs/DB00996
    ApprovedInvestigational

    [L8717] It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to treat neuropathic pain. … [A14097,A186179] Gabapentin has some stark advantages as compared with other anti-epileptics, such as a relatively benign adverse effect profile, wide therapeutic index, and lack of appreciable metabolism

    Mixtures: Innoprax-5, GAVINDO NSynonyms: 1-(Aminomethyl)cyclohexaneacetic acid
  10. Target

    Excretory Secretory (ES) proteins

    go.drugbank.com/bio_entities/BE0009630
    TargetFasciola hepatica

    Synonyms: Glutathione S-transferase omega classPolypeptides: Glutathione S-transferase omega class