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Displaying results 831 - 840 of 8171 in total

Drug
Propylthiouracil
go.drugbank.com/drugs/DB00550
Approved
A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharma...
Drug
Doxepin
go.drugbank.com/drugs/DB01142
ApprovedInvestigational
[L5977] Doxepin was developed by Pfizer and FDA approved in 1969 as an antidepressant.[L5971] However, in 2010 it was approved for the treatment of insomnia. … [T559] It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture.
Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
Drug
Gluconic Acid
go.drugbank.com/drugs/DB13180
ApprovedInvestigational
Commonly found in salts with sodium and calcium. Gluconic acid or gluconate is used to maintain the cation-anion balance on electrolyte solutions.
Synonyms: D-Gluconic AcidMixtures: ELETTROLITICA DI REINTEGRAZIONE PH 7,4 CON SODIO GLUCONATO FKI, ELETTROLITICA DI REINTEGRAZIONE PH 7,4 CON SODIO GLUCONATO FKI
Drug
Acepromazine
go.drugbank.com/drugs/DB01614
InvestigationalVet approved
Acepromazine is one of the phenothiazine derivative psychotropic drugs, used little in humans, however frequently in animals as a sedative and antiemetic.
Categories: Dopamine D2 Receptor Antagonists
Drug
Lufotrelvir
go.drugbank.com/drugs/DB16514
Investigational
Once administered through intravenous infusion, the compound is cleaved into PF-00835231 to exert its anti-viral effects[L31718]. … Phase 1b studies are also exploring the safety and tolerability of PF-07304814 in COVID-19 patients who are hospitalized (NCT04535167).
Drug
Empagliflozin
go.drugbank.com/drugs/DB09038
ApprovedInvestigational
Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. … [A203453] It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 diabetes mellitus.
Synonyms: (1S)-1,5-anhydro-1-(4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl)-D-glucitolMixtures: JARDIANZ DUO, JARDIANCE DUO
Drug
Pegloticase
go.drugbank.com/drugs/DB09208
ApprovedInvestigational
Pegloticase is a porcine recombinant PEGylated uricase indicated for the treatment of chronic gout in adult patients that do not respond to other types of therapies. … Therefore therapeutic drug levels can be maintained with infrequent and relatively low pegloticase doses.[A249980] The PEG group also gives pegloticase a lower potential to induce an immune response.
Drug
Ferric oxide
go.drugbank.com/drugs/DB11576
ApprovedInvestigational
Iron(III) oxide or ferric oxide is the inorganic compound with the formula Fe2O3. It is one of the three main oxides of iron, the other two being iron(II) oxide (FeO) the rarer form, and iron(II,III) oxide (Fe3O4) which naturally as magn...
Mixtures: Au Kah Chuen Fugical, OXIDO DE ZINC - CALAMINA UNGUENTO
Drug
Sertindole
go.drugbank.com/drugs/DB06144
ApprovedWithdrawn
Sertindole, a neuroleptic, is one of the newer antipsychotic medications available. Serdolect is developed by the Danish pharmaceutical company H. Lundbeck. It is a phenylindole derivative used in the treatment of schizophrenia. It was f...
Categories: Dopamine D2 Receptor Antagonists, Cytochrome P-450 Substrates
Drug
Drospirenone
go.drugbank.com/drugs/DB01395
ApprovedInvestigational
Drospirenone has been the subject of widespread safety concern due to the possibility of an increased risk of venous thromboembolism associated with its use. … [L7973] Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol] as an oral contraceptive therapy.
Mixtures: ACTIVA DE +TABLETAS RECUBIERTASCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates