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Displaying results 851 - 860 of 10000 in total
  1. Drug

    Glatiramer

    go.drugbank.com/drugs/DB05259
    ApprovedInvestigational

    [A248880] It was approved by the FDA in 1996, and a generic version became available in 2017. … [A248870] Along with [human interferon beta], [teriflunomide], and [dimethyl fumarate], glatiramer acetate is a first-line drug for patients with MS.

    Synonyms: Copolymer I (synthetic peptide), (T,G)-A-LProducts: Copaxone 20 mg/ml Injektionslösung in einer Fertigspritze, Copaxone 40 mg/ml Injektionslösung in einer Fertigspritze
  2. Drug

    Urofollitropin

    go.drugbank.com/drugs/DB00094
    ApprovedVet approvedWithdrawn

    Urofollitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF). … Urofollitropin is typically used injected subcutaneously in combination with human chorionic gonadotropin (hCG) to induce ovulation.

    Mixtures: Fertinorm Hp 75 - Pws Diluent Im Sc, Fertinorm Hp 150 - Pws Diluent Im ScCategories: Sex Hormones and Modulators of the Genital System
  3. Drug

    Eplerenone

    go.drugbank.com/drugs/DB00700
    ApprovedInvestigational

    Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative … The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: EPLERENONE DOC GENERICI, INSPRA IC
  4. Drug

    Lidocaine

    go.drugbank.com/drugs/DB00281
    ApprovedInvestigationalVet approved

    Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. … In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety

    Synonyms: 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide, 2-(Diethylamino)-2',6'-acetoxylidideInternational brands: L-Caine, Lidoject-1
  5. Drug

    Perindopril

    go.drugbank.com/drugs/DB00790
    ApprovedInvestigational

    Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). … It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration.

    Mixtures: PERINDO/IN RAT T 5/1.25, PERINDO/IN RAT T 5/1.25Categories: Agents Acting on the Renin-Angiotensin System, Heterocyclic Compounds, 2-Ring
  6. Drug

    Bicalutamide

    go.drugbank.com/drugs/DB01128
    ApprovedInvestigational

    Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. … Bicalutamide binds to the androgen receptor.

    Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, P-glycoprotein inhibitorsProducts: BICALUTAMIDE MYLAN GENERICS, BICALUTAMIDE DOC GENERICI
  7. Drug

    Sugammadex

    go.drugbank.com/drugs/DB06206
    ApprovedInvestigational

    Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015. … Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery.

    Categories: Compounds used in a research, industrial, or household settingProducts: SUGAMMADEX DR. REDDY'S, Sugammadex Aguettant 10 mg/ml Injektionslösung in einer Fertigspritze
  8. Drug

    Bivalirudin

    go.drugbank.com/drugs/DB00006
    ApprovedInvestigational

    Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. … Because it can cause blood stagnation, it is important to monitor changes in hematocrit, activated partial thromboplastin time, international normalized ratio and blood pressure.

    Products: Bivalirudin in 0.9% Sodium Chloride, OBIVADIN 250 MG IV ENJEKSIYON/INFÜZYON IÇIN LIYOFILIZE TOZ, 1 ADET
  9. Target

    UDP-3-O-acyl-N-acetylglucosamine deacetylase

    go.drugbank.com/bio_entities/BE0001333
    TargetAquifex aeolicus (strain VF5)

    Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

    Polypeptides: UDP-3-O-acyl-N-acetylglucosamine deacetylaseSynonyms: UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
  10. Target

    Heparan sulfate glucosamine 3-O-sulfotransferase 3A1

    go.drugbank.com/bio_entities/BE0001541
    TargetHumans

    Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2 (PubMed:10520990, PubMed:15304505, PubMed:9988768). … Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate

    Polypeptides: Heparan sulfate glucosamine 3-O-sulfotransferase 3A1Synonyms: Heparan sulfate 3-O-sulfotransferase 3A1, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1