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Granisetron
go.drugbank.com/drugs/DB00889ApprovedInvestigationalA serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: GRANIDUR 3 MG/3 ML ENJEKSIYONLUK ÇÖZELTI, 5 ADET, GRANIDUR 3 MG/3 ML ENJEKSIYONLUK ÇÖZELTI, 1 AMPULBenzylpenicilloyl polylysine
go.drugbank.com/drugs/DB00895ApprovedInvestigationalBenzylpenicilloyl polylysine is used as a skin-testing reagent to detect immunoglobulin E antibodies in people with a history of penicillin allergy. … The quantitation of in vitro IgE antibodies to the benzylpenicilloyl determinant is a useful tool for evaluating allergic subjects.
Categories: Heterocyclic Compounds, 2-RingSynonyms: Benzylpenicilloyl G polylysineMethdilazine
go.drugbank.com/drugs/DB00902ApprovedMethdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus.
Categories: Heterocyclic Compounds, 3-RingCocaine
go.drugbank.com/drugs/DB00907ApprovedIllicitInvestigationalIt is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. … It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester, methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylatePhenformin
go.drugbank.com/drugs/DB00914ApprovedWithdrawnAlthough it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. … A biguanide hypoglycemic agent with actions and uses similar to those of metformin.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesSynonyms: β-PhenethybiguanideAlmotriptan
go.drugbank.com/drugs/DB00918ApprovedAlmotriptan is a triptan drug for the treatment of migraine headaches. Almotriptan is in a class of medications called selective serotonin receptor agonists.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingSynonyms: 1-(((3-(2-(Dimethylamino)ethyl)indol-5-yl)methyl)sulfonyl)pyrrolidineLevosimendan
go.drugbank.com/drugs/DB00922ApprovedInvestigationalWithdrawnLevosimendan increases calcium sensitivity to myocytes by binding to troponin C in a calcium dependent manner. This increases contractility without raising calcium levels. … Levosimendan is used to manage acutely decompensated congestive heart failure.
Categories: Heterocyclic Compounds, 1-Ring, Phosphodiesterase 3 InhibitorsProducts: SIMDAX 2.5 MG/ML KONSANTRE INF.COZ.5 ML X FLAKON, 1 ADET, DAXIM® 2.5 MG / MLCeforanide
go.drugbank.com/drugs/DB00923ApprovedCeforanide is administered parenterally. It has a longer elimination half-life than any currently available cephalosporin. … Its activity is very similar to that of cefamandole, another second-generation cephalosporin antibiotic, except that ceforanide is less active against most gram-positive organisms.
Categories: Heterocyclic Compounds, 2-RingSynonyms: (6R,7R)-7-[[2-[2-(aminomethyl)phenyl]acetyl]amino]-3-[[1-(carboxymethyl)tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[O-(aminomethyl)phenylacetamido]-3-[[[1-(carboxymethyl)-1H-tetrazol-5-yl]thio]methyl]-3-cephem-4-carboxylic acidEtretinate
go.drugbank.com/drugs/DB00926ApprovedWithdrawnEtretinate is a medication used to treat severe psoriasis. It is a synthetic aromatic retinoid. … Etretinate is now used to treat T-cell lymphomas. It also appears to inhibit NADH oxidase activity.
Famotidine
go.drugbank.com/drugs/DB00927ApprovedInvestigationalFamotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. … [L11166] Compared to other H<sub>2</sub> receptor antagonists, famotidine displays high selectivity towards this receptor; in a study consisting of healthy volunteers and patients with acid hypersecretory
Synonyms: 3-(((2-((Diaminomethylene)amino)-4-thiazolyl)methyl)thio)-N(sup 2)-sulfamoylpropionamidine, N-Sulfamoyl-3-((2-guanidinothiazol-4-yl)methylthio)propionamideInternational brands: Sedanium-R