Benzylpenicilloyl polylysine is a penicillin derivative used to determine penicillin allergies. The quantitation of in vitro IgE antibodies to the benzylpenicilloyl determinant is a useful tool for evaluating allergic subjects.
- Mechanism
- Curator reviewed
The skin test for penicillin demonstrates the presence or absence of specific IgE antibodies to major and minor penicillin determinants. IgE antibodies to major determinants can be detected by using benzylpenicilloyl polylysine. A penicillin skin test predicts only the presence of IgE antibodies for the major or minor penicillin determinants at the time of application and does not predict the future development of IgE-mediated reactions during subsequent courses of penicillin. Benzylpenicilloyl polylysine reacts specifically with penicilloyl skin sensitizing antibodies (reagins) to produce immediate wheal and flare reactions which may reflect increased risk of allergic reactions to subsequent penicillin therapy.
- Primary indication
- For use as a adjunct in assessing the risk of administering penicillin (benzylpenicillin or penicillin G).Curator reviewed · 2 structured indications
- Formula / weight
- C28H46N6O8S · 626.765 g/mol (avg)
- First approval
- Canada, 2000 · United States, 1974
- Also known as
- Benzyl penicilloyl-polylysine · Benzylpenicilloyl G polylysine · Benzylpenicilloyl-polylysine
- Brand names
Resolves to
What you can answer from here — as of September 12, 2026
Which drugs share a target with Benzylpenicilloyl polylysine, and which of those have an active Phase 3 trial?
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